Henry Julie D, Crawford John R, Phillips Louise H
School of Psychology, King's College, University of Aberdeen, Aberdeen, Scotland.
Neuropsychology. 2005 Mar;19(2):243-52. doi: 10.1037/0894-4105.19.2.243.
A meta-analysis of 30 studies with 1,511 participants was conducted to estimate and compare the magnitude of deficits on tests of phonemic and semantic fluency for patients with Huntington's disease (HD) relative to healthy control participants. As has been found for patients with focal frontal cortical lesions (but not for patients with focal temporal cortical lesions), symptomatic HD patients were comparably impaired on tests of phonemic and semantic fluency (rs=.71 and .73, respectively). However, in contrast to patients with focal frontal lobe injuries, fluency deficits did not qualify as differential deficits relative to verbal intelligence or psychomotor speed. Therefore, for patients with HD, deficits on tests of phonemic and semantic fluency do not appear to reflect executive dysfunction but a more generalized cognitive impairment.
对30项研究（涉及1511名参与者）进行了一项荟萃分析，以估计和比较亨廷顿舞蹈症（HD）患者与健康对照参与者在音素流畅性和语义流畅性测试中的缺陷程度。正如局灶性额叶皮质病变患者（而非局灶性颞叶皮质病变患者）的情况一样，有症状的HD患者在音素流畅性和语义流畅性测试中受到的损害相当（相关系数分别为0.71和0.73）。然而，与局灶性额叶损伤患者不同的是，相对于言语智力或心理运动速度，流畅性缺陷并不属于差异性缺陷。因此，对于HD患者来说，音素流畅性和语义流畅性测试中的缺陷似乎并不反映执行功能障碍，而是更普遍的认知损害。
