Bresson Damien, Rebuffat Sandra A, Péraldi-Roux Sylvie
CNRS UMR 5160, Centre de Pharmacologie et Biotechnologie pour la Santé, Faculté de Pharmacie, 15 avenue Charles Flahault, BP 14491, 34093 Montpellier Cedex 5, France.
J Autoimmune Dis. 2005 Mar 15;2(1):2. doi: 10.1186/1740-2557-2-2.
Recent studies in the field of autoimmune thyroid diseases have largely focused on the delineation of B-cell auto-epitopes recognized by the main autoantigens to improve our understanding of how these molecules are seen by the immune system. Among these autoantigens which are targeted by autoantibodies during the development of autoimmune thyroid diseases, thyroid peroxidase is a major player. Indeed, high amounts of anti-thyroid peroxidase autoantibodies are found in the sera of patients suffering from Graves' disease and Hashimoto's thyroiditis, respectively hyper and hypothyroidism. Since anti-thyroid peroxidase autoantibodies from patients'sera mainly recognize a discontinuous immunodominant region on thyroid peroxidase and due to the complexity of the three dimensional structure of human thyroid peroxidase, numerous investigations have been necessary to closely localize this immunodominant region. The aim of the present review is to summarize the current knowledge regarding the localization of the immunodominant region recognized by human thyroid peroxidase-specific autoantibodies generated during the development of autoimmune thyroid diseases.
自身免疫性甲状腺疾病领域的近期研究主要集中在确定主要自身抗原所识别的B细胞自身表位，以增进我们对免疫系统如何看待这些分子的理解。在自身免疫性甲状腺疾病发展过程中被自身抗体靶向的这些自身抗原中，甲状腺过氧化物酶是主要角色。事实上，分别在患有格雷夫斯病（甲亢）和桥本甲状腺炎（甲减）患者的血清中发现了大量抗甲状腺过氧化物酶自身抗体。由于患者血清中的抗甲状腺过氧化物酶自身抗体主要识别甲状腺过氧化物酶上一个不连续的免疫显性区域，且由于人甲状腺过氧化物酶三维结构的复杂性，需要进行大量研究来精确确定这个免疫显性区域的位置。本综述的目的是总结目前关于自身免疫性甲状腺疾病发展过程中产生的人甲状腺过氧化物酶特异性自身抗体所识别的免疫显性区域定位的知识。
