Menees Stacy, Elta Grace H
Division of Gastroenterology, University of Michigan, 3912 Taubman Center, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA. E-mail:
Curr Treat Options Gastroenterol. 2005 Apr;8(2):109-115. doi: 10.1007/s11938-005-0003-2.
Sphincter of Oddi dysfunction (SOD) is a benign noncalculous obstruction of bile or pancreatic drainage at the level of the sphincter of Oddi. The disorder is clinically associated with either biliary pain or idiopathic pancreatitis, depending on the portion of the sphincter affected. Patients with suspected SOD are subdivided into three categories: these are type I, II, and III, depending on associated clinical evidence for the diagnosis. Multiple noninvasive tests have been utilized to aid in the diagnosis but have been complicated by poor sensitivity and specificity. Sphincter of Oddi manometry is the gold standard for confirming the diagnosis, although questions remain about its sensitivity and specificity. Sphincterotomy of the affected portion of the sphincter is the treatment of choice and has been shown effective for palliation of symptoms in two sham-controlled studies of patients with suspected type II biliary SOD.
奥狄括约肌功能障碍（SOD）是指奥狄括约肌水平处胆汁或胰液引流的良性非结石性梗阻。根据受影响的括约肌部位不同，该疾病在临床上与胆绞痛或特发性胰腺炎相关。疑似SOD的患者根据诊断的相关临床证据分为三类：即I型、II型和III型。多种非侵入性检查已被用于辅助诊断，但因敏感性和特异性较差而变得复杂。奥狄括约肌测压是确诊的金标准，尽管其敏感性和特异性仍存在疑问。对括约肌受影响部分进行括约肌切开术是首选治疗方法，并且在两项针对疑似II型胆源性SOD患者的假对照研究中已显示出对症状缓解有效。
