Aoyama Yuri
Department of Bioinformatics, Faculty of Engineering, Soka University, Hachioji, Tokyo, Japan.
Front Biosci. 2005 May 1;10:1546-57. doi: 10.2741/1639.
CYP51 (sterol 14-demethylase P450) is a family of P450 species having the same function in distinct kingdoms, which makes CYP51 a unique and important enzyme family for the discussion of evolution and diversification of P450. Although CYP51 was named to the P450 originally discovered in yeast and fungi, today, we know that members of CYP51 family exist ubiquitously in animals, plants, fishes, lower eukaryotes such as slime mold, and a part of bacteria. In this review, I describe following subjects: 1) CYP51 as a model family for understanding of diversification of P450, 2) the structure and function relationships of CYP51s.
CYP51（甾醇14-去甲基化酶P450）是一类在不同生物界具有相同功能的P450酶家族，这使得CYP51成为讨论P450进化和多样化的独特且重要的酶家族。尽管CYP51最初是根据在酵母和真菌中发现的P450命名的，但如今我们知道CYP51家族成员广泛存在于动物、植物、鱼类、黏菌等低等真核生物以及部分细菌中。在本综述中，我将描述以下主题：1）作为理解P450多样化的模型家族的CYP51；以及CYP51的结构与功能关系。
