Paroli Marino, Barnaba Vincenzo
Andrea Cesalpino Foundation, Department of Internal Medicine, La Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
Front Biosci. 2005 May 1;10:1628-34. doi: 10.2741/1646.
CD8+ T cells represent a powerful arm of the adaptive immunity that is particularly effective against intracellular pathogens. These cells might also participate in the generation and sustenance of autoimmune responses. The escape of a certain number of CD8+ autoreactive T lymphocytes from thymic negative selection occurs normally in all individuals, but this event is rarely associated with the onset of autoimmune diseases. Several peripheral mechanisms have been evolved by the immune system to take control of these potentially harmful self-aggressive cytotoxic CD8+ T cells. In the present review, we will discuss the principal strategies by which the immune system is capable of maintaining CD8+ T cell tolerance to self, thus making them ineffective to harm their own host but still capable to defend the host against foreign invaders.
CD8 + T细胞是适应性免疫的强大力量，对细胞内病原体特别有效。这些细胞也可能参与自身免疫反应的产生和维持。一定数量的CD8 +自身反应性T淋巴细胞从胸腺阴性选择中逃逸在所有个体中通常都会发生，但这一事件很少与自身免疫性疾病的发作相关。免疫系统已经进化出几种外周机制来控制这些潜在有害的自身攻击性细胞毒性CD8 + T细胞。在本综述中，我们将讨论免疫系统能够维持CD8 + T细胞对自身耐受性的主要策略，从而使它们无法伤害自身宿主，但仍能够保护宿主抵御外来入侵者。
