Silvestri Tania, Pulsatelli Lia, Dolzani Paolo, Frizziero Luigi, Facchini Andrea, Meliconi Riccardo
Laboratorio di Immunologia e Genetica, Istituto Codivilla-Putti, Istituti Ortopedici Rizzoli, Via di Barbiano 1/10, Bologna, Italy.
Rheumatol Int. 2006 Feb;26(4):360-8. doi: 10.1007/s00296-005-0586-x. Epub 2005 Mar 16.
To test a hypothesis of compartmentalized pathogenesis of different types of arthritis, namely inflammatory arthritis (IA) and osteoarthritis (OA), synovial and cartilage biopsies were examined for the expression of TNF and IL-1 receptors. In cartilage, we found constitutive expression of all receptors in normal tissues, and decreased expression of signal-transducing receptors in pathological chondrocytes. In synovium, there was a lower expression of signal-transducing receptors in cases of OA compared to those of IA. In OA, the three signal-transducing receptors were more abundantly expressed in cartilage, while in IA they were mainly present in synovial tissue (TNFRp75 being expressed more than p55). IL-1 decoy receptor type II was low or absent in synovial tissues, but present in cartilage. The increased expression of TNFRp75 and IL-1RI in OA cartilage, compared to IA, in addition to the abundant local cytokine production, strengthens the hypothesis of autocrine/paracrine action by inflammatory cytokines in the pathogenesis of cartilage damage.
为了验证不同类型关节炎（即炎性关节炎（IA）和骨关节炎（OA））的分隔式发病机制假说，对滑膜和软骨活检样本进行检测，以观察肿瘤坏死因子（TNF）和白细胞介素-1（IL-1）受体的表达情况。在软骨中，我们发现正常组织中所有受体均有组成性表达，而在病理性软骨细胞中信号转导受体的表达降低。在滑膜中，与IA相比，OA病例中信号转导受体的表达较低。在OA中，三种信号转导受体在软骨中表达更为丰富，而在IA中它们主要存在于滑膜组织中（TNFRp75的表达量高于p55）。IL-1 II型诱饵受体在滑膜组织中表达较低或缺失，但在软骨中存在。与IA相比，OA软骨中TNFRp75和IL-1RI的表达增加，再加上局部细胞因子大量产生，强化了炎性细胞因子在软骨损伤发病机制中通过自分泌/旁分泌作用的假说。
