锝-99m亚甲基二膦酸盐骨闪烁显像用于评估非清髓性外周血干细胞移植后慢性移植物抗宿主病表现的肌炎。

Tc-99m MDP bone scintigraphy of myositis as a manifestation of chronic graft-versus-host disease after non-myeloablative peripheral stem cell transplantation.

作者信息

Mitomo Maki, Miyazaki Chihoko, Mukai Masaya, Usami Yohko, Nagano Shunsuke, Nakamura Noriko, Kubo Kohzoh

机构信息

Department of Medical Imaging, Sapporo City General Hospital, Japan.

出版信息

Ann Nucl Med. 2005 Feb;19(1):41-5. doi: 10.1007/BF02986334.

DOI:10.1007/BF02986334

PMID:15770972

Abstract

A 27-year-old man developed polymyositis as a manifestation of chronic graft-versus-host disease (GVHD) after non-myeloablative peripheral blood stem cell transplantation (PBSCT). Bone scintigraphy showed intense, striped, and heterogeneous accumulation of Tc-99m methylene diphosphonate (MDP) in the soft-tissue of his lower limbs, while faint activities were seen in the right upper limb. Tc-99m MDP scintigraphy was very useful for accurate and objective evaluation of the severity of the muscle injury and the extent of polymyositis caused by chronic GVHD.

摘要

一名27岁男性在非清髓性外周血干细胞移植（PBSCT）后发生了多肌炎，这是慢性移植物抗宿主病（GVHD）的一种表现。骨闪烁显像显示，他双下肢软组织中锝-99m亚甲基二膦酸盐（MDP）呈强烈、条纹状且不均匀的聚集，而右上肢仅见微弱放射性。锝-99m MDP闪烁显像对于准确、客观地评估慢性GVHD所致肌肉损伤的严重程度及多肌炎范围非常有用。