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抗感染药物药代动力学/药效学(PK/PD)术语的标准化:更新版

Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs: an update.

作者信息

Mouton Johan W, Dudley Michael N, Cars Otto, Derendorf Hartmut, Drusano George L

机构信息

Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Weg door Jonkerbos 100, 6532 sz Nijmegen, The Netherlands.

出版信息

J Antimicrob Chemother. 2005 May;55(5):601-7. doi: 10.1093/jac/dki079. Epub 2005 Mar 16.

Abstract

Interest in the relationships between the pharmacokinetics (PK) and pharmacodynamics (PD) of antimicrobial agents has increased over recent years. Since the appearance 2 years ago of our first article describing terminology in PK/PD, the field has continued to expand rapidly, urgently requiring an update. This paper describes in a uniform manner the use of PK/PD expressions for antimicrobial agents, and their units.

摘要

近年来,对抗菌药物药代动力学(PK)和药效学(PD)之间关系的关注有所增加。自从我们两年前发表第一篇描述PK/PD术语的文章以来,该领域一直在迅速扩展,迫切需要更新。本文以统一的方式描述了抗菌药物PK/PD表达式及其单位的使用。

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