基于间充质干细胞的软骨组织工程：细胞、支架与生物学

Mesenchymal stem cell-based cartilage tissue engineering: cells, scaffold and biology.

作者信息

Song L, Baksh D, Tuan R S

机构信息

Cartilage Biology and Orthopedics Branch, National Institute of Arthritis, and Musculoskeletal and Skin Diseases, Department of Health and Human Services, NIH, Bethesda, MD 20892-8022, USA.

出版信息

Cytotherapy. 2004;6(6):596-601. doi: 10.1080/14653240410005276-1.

DOI:10.1080/14653240410005276-1

PMID:15773023

Abstract

Cartilage repair and regeneration by stem cell-based tissue engineering could be of enormous therapeutic and economic potential benefit for an aging population. However, to use stem cells effectively, their natural environment must be understood in order to expand them in vitro without compromising their multilineage potential and their specific differentiation program. Collaboration between diverse academic disciplines and between research and regulatory government agencies and industry is crucial before cell-based cartilage tissue engineering can achieve its full therapeutic potential.

摘要

基于干细胞的组织工程进行软骨修复和再生，对于老龄化人口而言可能具有巨大的治疗和经济潜在益处。然而，为了有效利用干细胞，必须了解它们的自然环境，以便在体外扩增它们而不损害其多系分化潜能和特定分化程序。在基于细胞的软骨组织工程能够充分发挥其治疗潜力之前，不同学科之间以及研究机构、政府监管机构和产业之间的合作至关重要。