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前侧与后侧部分胃底折叠术后胃食管交界处的测压特征

Manometric characteristics of the gastroesophageal junction after anterior versus posterior partial fundoplication.

作者信息

Engström C, Ruth M, Lönroth H, Lundell L

机构信息

Department of Surgery, Sahlgrenska University Hospital, Göteborg University, S-413 45 Göteborg, Sweden.

出版信息

Dis Esophagus. 2005;18(1):31-6. doi: 10.1111/j.1442-2050.2005.00445.x.

Abstract

How best to surgically treat GERD is an unresolved issue. To increase our insights into the fundoplication procedures, functional consequences for the gastroesophageal junction of an anterior or a posterior partial fundoplication were studied by manometry. Patients were randomly selected from a larger study in a randomised comparison between posterior and anterior partial fundoplications. The manometric studies were done 12 months after respective procedures in 24 patients. The motor characteristics of the esophagus and lower esophageal sphincter (LES) function were determined by use of sleeve catheter manometry. The manometric characteristics of the esophageal body were similar in the study groups except for the ramp pressure. This was significantly higher in patients with posterior partial fundoplications. The posterior group had significantly longer total length (P < 0.02) as well as longer intra-abdominal portions (P = 0.07) of the LES while the basal tone, albeit numerically higher, did not reach statistical significance. Water-swallow induced LES relaxations reached lower nadir values in the anterior group (1.7 vs 2.7 mmHg). Gas distension triggered few transient LES relaxations in both study groups while common cavities were more frequently observed in those having an anterior partial wrap (P < 0.01). A posterior partial fundoplication is followed by manometric characteristics suggesting a well functioning antireflux barrier with some obstruction to bolus passage as well as restricted venting of air from the stomach. The manometric mechanisms behind the inferior reflux control achieved by a Watson type of anterior partial wrap has now been further elucidated.

摘要

如何以最佳方式通过手术治疗胃食管反流病(GERD)仍是一个未解决的问题。为了深入了解胃底折叠术,我们通过测压研究了前侧或后侧部分胃底折叠术对胃食管交界处的功能影响。患者是从一项关于后侧和前侧部分胃底折叠术随机对照的大型研究中随机选取的。在各自手术12个月后,对24例患者进行了测压研究。使用套囊导管测压法测定食管和食管下括约肌(LES)功能的运动特征。除斜坡压外,各研究组食管体的测压特征相似。后侧部分胃底折叠术患者的斜坡压明显更高。后侧组LES的总长度明显更长(P < 0.02),腹内段也更长(P = 0.07),尽管基础张力数值上更高,但未达到统计学显著性。在前侧组,吞水诱导的LES松弛达到的最低点值更低(1.7 mmHg对2.7 mmHg)。在两个研究组中,气体扩张引发的LES短暂松弛较少,而在前侧部分包裹的患者中更频繁观察到共同腔(P < 0.01)。后侧部分胃底折叠术后的测压特征表明存在一个功能良好的抗反流屏障,但对食团通过有一定阻碍,且胃内空气排出受限。现在进一步阐明了沃森式前侧部分包裹术实现较差反流控制背后的测压机制。

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