Flexible peptides and cytoplasmic gels.

Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, UK.

Genome Biol. 2005;6(3):106. doi: 10.1186/gb-2005-6-3-106. Epub 2005 Feb 28.

Recent progress in predicting protein structures has revealed a surprising abundance of proteins that are significantly unfolded under physiological conditions. Unstructured, flexible polypeptides are likely to be functionally important and may cause local cytoplasmic regions to become gel-like.

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Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures.

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The hydrogel nature of mammalian cytoplasm contributes to osmosensing and extracellular pH sensing.

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Balls and chains--a mesoscopic approach to tethered protein domains.

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核心技术专利：CN118964589B侵权必究

Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, UK.

Genome Biol. 2005;6(3):106. doi: 10.1186/gb-2005-6-3-106. Epub 2005 Feb 28.

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Flexible peptides and cytoplasmic gels.

Genome Biol. 2005;6(3):106. doi: 10.1186/gb-2005-6-3-106. Epub 2005 Feb 28.

The structure of "unstructured" regions in peptides and proteins: role of the polyproline II helix in protein folding and recognition.

Biopolymers. 2005;80(2-3):179-85. doi: 10.1002/bip.20227.

Roles of molecular chaperones in cytoplasmic protein folding.

Semin Cell Dev Biol. 2000 Feb;11(1):15-25. doi: 10.1006/scdb.1999.0347.

Statics of the ribosomal exit tunnel: implications for cotranslational peptide folding, elongation regulation, and antibiotics binding.

J Mol Biol. 2009 Mar 27;387(2):502-17. doi: 10.1016/j.jmb.2009.01.037. Epub 2009 Jan 27.

Conformational propensities and residual structures in unfolded peptides and proteins.

Mol Biosyst. 2012 Jan;8(1):122-33. doi: 10.1039/c1mb05225j. Epub 2011 Aug 30.

Polymer models of protein stability, folding, and interactions.

Biochemistry. 2004 Mar 2;43(8):2141-54. doi: 10.1021/bi036269n.

Conformational characteristics of unstructured peptides: alpha-synuclein.

J Biomol Struct Dyn. 2008 Apr;25(5):505-15. doi: 10.1080/07391102.2008.10507197.

Origin of the sequence-dependent polyproline II structure in unfolded peptides.

Proteins. 2005 Dec 1;61(4):769-76. doi: 10.1002/prot.20655.

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J Chem Phys. 2013 Sep 28;139(12):121925. doi: 10.1063/1.4817215.

Conformational distributions of unfolded polypeptides from novel NMR techniques.

J Chem Phys. 2008 Feb 7;128(5):052204. doi: 10.1063/1.2838167.

引用本文的文献

Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures.

Am J Physiol Lung Cell Mol Physiol. 2013 Dec;305(12):L990-L1001. doi: 10.1152/ajplung.00103.2013. Epub 2013 Oct 11.

Identification of SPLUNC1's ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airways.

FASEB J. 2012 Oct;26(10):4348-59. doi: 10.1096/fj.12-207431. Epub 2012 Jul 13.

The hydrogel nature of mammalian cytoplasm contributes to osmosensing and extracellular pH sensing.

Biophys J. 2009 May 20;96(10):4276-85. doi: 10.1016/j.bpj.2009.02.038.

Balls and chains--a mesoscopic approach to tethered protein domains.

Biophys J. 2006 Oct 1;91(7):2383-92. doi: 10.1529/biophysj.105.078543. Epub 2006 Jul 7.

本文引用的文献

Adaptational assistance in clusters of bacterial chemoreceptors.

Mol Microbiol. 2005 Jun;56(6):1617-26. doi: 10.1111/j.1365-2958.2005.04641.x.

Comparing and combining predictors of mostly disordered proteins.

Biochemistry. 2005 Feb 15;44(6):1989-2000. doi: 10.1021/bi047993o.

Order changes within receptor systems upon ligand binding: receptor tightening/oligomerisation and the interpretation of binding parameters.

J Mol Biol. 2004 Jul 2;340(2):373-83. doi: 10.1016/j.jmb.2004.04.056.

Conformational spread: the propagation of allosteric states in large multiprotein complexes.

Annu Rev Biophys Biomol Struct. 2004;33:53-73. doi: 10.1146/annurev.biophys.33.110502.132703.

Functional interactions between receptors in bacterial chemotaxis.

Nature. 2004 Mar 25;428(6981):437-41. doi: 10.1038/nature02406.

Coupling of folding and binding of thymosin beta4 upon interaction with monomeric actin monitored by nuclear magnetic resonance.

J Biol Chem. 2004 May 28;279(22):23637-45. doi: 10.1074/jbc.M311413200. Epub 2004 Mar 22.

Attractant binding alters arrangement of chemoreceptor dimers within its cluster at a cell pole.

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3462-7. doi: 10.1073/pnas.0306660101. Epub 2004 Mar 1.

The importance of intrinsic disorder for protein phosphorylation.

Nucleic Acids Res. 2004 Feb 11;32(3):1037-49. doi: 10.1093/nar/gkh253. Print 2004.

Protein disorder prediction: implications for structural proteomics.

Structure. 2003 Nov;11(11):1453-9. doi: 10.1016/j.str.2003.10.002.

Ligand binding energy and catalytic efficiency from improved packing within receptors and enzymes.

J Mol Biol. 2003 May 30;329(2):389-99. doi: 10.1016/s0022-2836(03)00428-5.

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