Tsunoda Masaya
Department of Orthopaedic Surgery, Hyogo Prefectual Kakogawa Hospital.
Clin Calcium. 2003 Oct;13(10):1293-6.
Low intensity pulsed ultrasound (LIPUS) has been used for non-union and delayed-union since 1998 in Japan. The LIPUS signal is 200 microsecond sine wave of 1.5 MHz repeating at a frequency of 1 KHz. The intensity is 30 mW/cm(2) spatial and temporal average. Application of LIPUS to healing fractures has been shown to increase the mechanical strength of the callus, including torque and stiffness, and reduce the time to bone union in animal models and clinical trials. The mechanism of LIPUS for acceleration of fracture healing is still unclear, but we speculate that micro mechanical stress transferred by the ultrasound signal stimulates enchondral ossification. Success rates for non-union and delayed-union are 80% in Japan.
自1998年起，低强度脉冲超声（LIPUS）在日本被用于治疗骨不连和延迟愈合。LIPUS信号为1.5MHz的200微秒正弦波，以1kHz的频率重复。强度为空间和时间平均30mW/cm²。在动物模型和临床试验中，已证明将LIPUS应用于愈合中的骨折可提高骨痂的机械强度，包括扭矩和刚度，并缩短骨愈合时间。LIPUS加速骨折愈合的机制仍不清楚，但我们推测超声信号传递的微机械应力会刺激软骨内成骨。在日本，骨不连和延迟愈合的成功率为80%。
