Saito Tomoyuki, Koshino Tomihisa
Department of Orthopaedic Surgery, Yokohama City University School of Medicine.
Clin Calcium. 2002 Jan;12(1):59-62.
Neural elements are widely distributed in synovium of osteoarthritic knees. In medial compartmental osteoarthritic knees, medial synovium is exposed to mechanical stimuli due to osteophytes and lateral thrust, which may accumulate neuropeptides, especially substance P, in free nerve endings. Free nerve endings containing a large amount of substance P may provoke pain sensation in synovium, and release substance P to the surrounding tissue in subsynovial tissue, which induces synovitis. Neural system may modulate synovitis as well as pain pathway in osteoarthritis of the knee.
神经成分广泛分布于骨关节炎膝关节的滑膜中。在膝关节内侧间室骨关节炎中，内侧滑膜由于骨赘和侧向推力而受到机械刺激，这可能会使神经肽尤其是P物质在游离神经末梢中积聚。含有大量P物质的游离神经末梢可能会引发滑膜中的疼痛感，并向滑膜下组织周围的组织释放P物质，从而诱发滑膜炎。神经系统可能会调节膝关节骨关节炎中的滑膜炎以及疼痛通路。
