Laaff H, Mittelviefhaus H, Wokalek H, Schöpf E
Universitäts-Hautklinik Freiburg.
Hautarzt. 1992 Mar;43(3):143-7.
Eruptive Grzybowski-type keratoacanthoma is a rare variant of multiple keratoacanthoma and is not accompanied by internal malignancies. Up to now only 16 cases of eruptive Grzybowski-type keratoacanthoma have been described in the literature. Eruptive and solitary keratoacanthomas cannot be distinguished histologically. The multiplicity of skin lesions may be due to a genetic background. Our patient presented with multiple eruptive keratoacanthomas, ectropion and a mask-like face. Conservative treatment, e.g. with etretinate, did not lead to any improvement of symptoms in this case. Therefore surgical therapy was recommended for the patient's ectropion.
爆发性格日博夫斯基型角化棘皮瘤是多发性角化棘皮瘤的一种罕见变体,不伴有内脏恶性肿瘤。迄今为止,文献中仅描述了16例爆发性格日博夫斯基型角化棘皮瘤。爆发性和孤立性角化棘皮瘤在组织学上无法区分。皮肤病变的多发性可能归因于遗传背景。我们的患者表现为多发性爆发性角化棘皮瘤、睑外翻和面具样面容。在该病例中,保守治疗,如使用阿维A酯,并未使症状得到任何改善。因此,建议对该患者的睑外翻进行手术治疗。