Gjersvik P, Egass E, Clausen O P
Department of Dermatology, Rikshospitalet, University of Oslo, N-0027 Oslo, Norway.
Eur J Dermatol. 2000 Mar;10(2):135-8.
A 47-year old woman with Grzybowski's generalised eruptive keratoacanthomas is described. There was no history of skin disease in her family, except for an uncle's basal cell carcinoma. From 1995 she developed multiple lesions of various size, ranging from hundreds of small follicular lesions to large typical keratoacanthomas up to 5 cm in diameter, scleroderma-like facial skin and marked ectropion. Histological examination of small and large skin lesions was typical of keratoacanthoma, and no human papillomavirus was detected by polymerase chain reaction. Oral treatment with acitretin had no effect. Both cyclophosphamide and methotrexate therapy were refused by the patient despite the progressive course of the disease. Blepharoplastic surgery had some effect on eye symptoms. The etiology of this rare disease is unknown, but is probably related to some genetic defect.
本文描述了一名患有格日博夫斯基泛发性 eruptive 角化棘皮瘤的47岁女性。她的家族中除了一位叔叔患基底细胞癌外，没有皮肤病病史。从1995年起，她出现了大小各异的多个皮损，从数百个小毛囊性皮损到直径达5厘米的大型典型角化棘皮瘤，面部皮肤呈硬皮病样改变并伴有明显睑外翻。大小皮肤损害的组织学检查均为典型的角化棘皮瘤，聚合酶链反应未检测到人乳头瘤病毒。口服阿维A治疗无效。尽管疾病呈进行性发展，但患者拒绝了环磷酰胺和甲氨蝶呤治疗。眼睑整形手术对眼部症状有一定效果。这种罕见疾病的病因尚不清楚，但可能与某些基因缺陷有关。
