Rehrer N J, Goes E, DuGardeyn C, Reynaert H, DeMeirleir K
Department of Sports Medicine and Human Physiology, Academic Hospital, Free University of Brussels, Brussels, Belgium.
Int J Sports Med. 2005 Apr;26(3):171-6. doi: 10.1055/s-2004-820957.
Effects of carbohydrate ingestion and exercise on portal vein blood flow were studied. Flow was measured by pulsed-electronic Doppler. Eight male subjects performed four tests after a standardised breakfast and 5 h fast. Beverages were CHO (10 % glucose, 30 mmol . l (-1) NaCl) and W (water, 30 mmol . l (-1) NaCl). Exercise experiments comprised a resting measurement, 10 min warm-up and 60 min 70 % VO(2)max cycling. Every 10 min subjects stopped cycling briefly (approximately 30 s) for measurements. Beverage was consumed after warm-up (500 ml) and at 20 and 40 min (250 ml). Similar tests were done at rest. Blood samples were taken concurrently with flow measurements for hormonal concentrations. Exercise decreased blood flow (repeated measures ANOVA, p < 0.0001) and carbohydrate ingestion increased flow (p = 0.015). At rest, flow was greater with CHO than with W at 20 (177 +/- 31; 101 +/- 25 %, resp.) (mean +/- SE), 30 (209 +/- 37; 120 +/- 20 %), 40 (188 +/- 32; 108 +/- 12 %), and 60 min (195 +/- 19; 112 +/- 12 %) (1-way ANOVA, Fisher's PLSD, p < 0.05). Flow was similar during exercise with CHO and W, with a tendency for CHO to maintain flow better, at 10 (124 +/- 27; 77 +/- 21 %), 20 (81 +/- 10; 60 +/- 13 %), 30 (106 +/- 26; 56 +/- 10 %), 40 (109 +/- 28; 54 +/- 8 %), 50 (85 +/- 17; 54 +/- 13 %), and 60 min (61 +/- 15; 47 +/- 7 %). A positive correlation between glucagon and flow and an inverse correlation between noradrenaline and flow were observed. Exercise reduces, and carbohydrate increases, portal vein flow. Changes in plasma concentrations suggest that noradrenaline and glucagon, respectively, may play a role in modulating flow.
研究了碳水化合物摄入和运动对门静脉血流量的影响。血流量通过脉冲电子多普勒测量。八名男性受试者在标准化早餐和禁食5小时后进行了四项测试。饮料为碳水化合物饮料（10%葡萄糖，30 mmol·l⁻¹氯化钠）和水（水，30 mmol·l⁻¹氯化钠）。运动实验包括静息测量、10分钟热身和60分钟70%最大摄氧量的骑行。受试者每10分钟短暂停止骑行（约30秒）进行测量。热身（500毫升）后以及20分钟和40分钟时（250毫升）饮用饮料。在静息状态下进行了类似测试。在测量血流量的同时采集血样以检测激素浓度。运动使血流量减少（重复测量方差分析，p<0.0001），碳水化合物摄入使血流量增加（p = 0.015）。静息时，在20分钟（分别为177±31；101±25%）、30分钟（209±37；120±20%）、40分钟（188±32；108±12%）和60分钟（195±19；112±12%）时，碳水化合物饮料组的血流量高于水组（单因素方差分析，Fisher's PLSD，p<0.05）。在运动过程中，碳水化合物饮料组和水组的血流量相似，碳水化合物饮料组有更好地维持血流量的趋势，在10分钟（124±27；77±21%）、20分钟（81±10；60±13%）、30分钟（106±26；56±10%）、40分钟（109±28；54±8%）、50分钟（85±17；54±13%）和60分钟（61±15；47±7%）时。观察到胰高血糖素与血流量呈正相关，去甲肾上腺素与血流量呈负相关。运动减少门静脉血流量，碳水化合物增加门静脉血流量。血浆浓度的变化表明，去甲肾上腺素和胰高血糖素可能分别在调节血流量中起作用。
