重复经颅磁刺激诱导大鼠海马缺血耐受的研究
Acquisition of ischemic tolerance by repetitive transcranial magnetic stimulation in the rat hippocampus.
作者信息
Ogiue-Ikeda Mari, Kawato Suguru, Ueno Shoogo
机构信息
Department of Biomedical Engineering, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
出版信息
Brain Res. 2005 Mar 10;1037(1-2):7-11. doi: 10.1016/j.brainres.2004.10.063.
We investigated the acquisition of ischemic tolerance in the rat hippocampus using repetitive transcranial magnetic stimulation (rTMS). Rats received 1000 pulses/day for 7 days, and the field excitatory postsynaptic potentials were measured in the hippocampal CA1. After slices were exposed to ischemic conditions, long-term potentiation (LTP) was induced. The LTP of the stimulated group was enhanced compared with the LTP of the sham control group in each ischemic condition, suggesting that rTMS has the potential to protect hippocampal function from ischemia.
我们使用重复经颅磁刺激（rTMS）研究了大鼠海马体中缺血耐受性的获得情况。大鼠每天接受1000次脉冲，持续7天，并在海马CA1区测量场兴奋性突触后电位。在切片暴露于缺血条件后，诱导长时程增强（LTP）。在每种缺血条件下，刺激组的LTP均比假手术对照组的LTP增强，这表明rTMS有保护海马功能免受缺血影响的潜力。
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