最大雄激素阻断疗法（MAB）的有效性：是幻觉还是现实？
Effectiveness of Maximal Androgen Blockade (MAB): illusion or reality?
作者信息
Akaza Hideyuki
机构信息
Department of Urology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
出版信息
Can J Urol. 2005 Feb;12 Suppl 1:77-80.
Two decades have passed since the concept of Maximal Androgen Blockade (MAB) was first applied to the clinical treatment of prostate cancer. The theory is that by cutting off the supply of androgen from the adrenal gland, androgen blockade of the prostate could be made more complete. However, to date the clinical benefit of MAB has failed to live up to the theoretically expected effect. Having said that, fundamental research and clinical trials in recent years do indicate that the benefit of MAB is not merely an illusion.
自最大雄激素阻断（MAB）概念首次应用于前列腺癌的临床治疗以来，已经过去了二十年。其理论是，通过切断肾上腺雄激素的供应，可以使前列腺的雄激素阻断更加彻底。然而，迄今为止，MAB的临床益处并未达到理论上预期的效果。话虽如此，近年来的基础研究和临床试验确实表明，MAB的益处并非仅仅是一种错觉。
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