透明质酸链的构象与动力学

Hyaluronan chain conformation and dynamics.

作者信息

Furlan Sara, La Penna Giovanni, Perico Angelo, Cesàro Attilio

机构信息

Department of Biochemistry, Biophysics and Macromolecular Chemistry, UdR INSTM, University of Trieste, I-34127 Trieste, Italy.

出版信息

Carbohydr Res. 2005 Apr 11;340(5):959-70. doi: 10.1016/j.carres.2005.01.030.

DOI:10.1016/j.carres.2005.01.030

PMID:15780260

Abstract

An overview of the present state of research in the field of hyaluronan chain conformational aspects is presented. The relationship between structure and dynamics are illustrated for a series of hyaluronan oligomers. Conformational characteristics of hyaluronan chains are discussed, together with the dynamic chain patterns, evaluated by using a theoretical approach to diffusive polymer dynamics. The dependence of correlation times and NMR relaxation parameters from the chain dimension are investigated. Topological features and dimensional properties are related to the structural determinants by using classical computational methods of molecular mechanics and Monte Carlo simulation.

摘要

本文综述了透明质酸链构象方面的研究现状。阐述了一系列透明质酸低聚物的结构与动力学之间的关系。讨论了透明质酸链的构象特征以及通过扩散聚合物动力学的理论方法评估的动态链模式。研究了相关时间和核磁共振弛豫参数对链尺寸的依赖性。通过使用分子力学和蒙特卡罗模拟的经典计算方法，将拓扑特征和尺寸特性与结构决定因素联系起来。