Ahmad Nazim Ali, Memon Amanullah, Hussainy Akbar
Department of Surgery, The Aga Khan University, Karachi, Pakistan.
Urology. 2005 Mar;65(3):591. doi: 10.1016/j.urology.2004.09.057.
Urethral adenocarcinoma is the least common histologic subtype of a rare primary carcinoma of the male urethra. Its site of origin remains speculative. The scarcity of reported cases in the literature makes it difficult to define the optimal management. This report is of a 40-year-old morbidly obese man with synchronous adenocarcinoma of the bulbar urethra and bladder, treated surgically by en bloc abdominoperineal penoprostatocystectomy. The pleural recurrence, after a disease-free period of 2 years, responded well to platinum-docetaxel-based systemic chemotherapy. Synchronous occurrence of adenocarcinoma of the urethra and bladder has not been previously reported. This case also highlights the possible role of upcoming adjuvant chemotherapeutic agents.
尿道腺癌是男性尿道罕见原发性癌中最不常见的组织学亚型。其起源部位仍存在推测。文献中报道病例的稀缺使得难以确定最佳治疗方案。本报告介绍了一名40岁的病态肥胖男性，患有球部尿道和膀胱同步腺癌，通过整块经腹会阴阴茎前列腺膀胱切除术进行手术治疗。在无病生存期2年后出现胸膜复发，对基于铂-多西他赛的全身化疗反应良好。尿道和膀胱腺癌的同步发生此前尚未见报道。该病例还突出了即将出现的辅助化疗药物可能发挥的作用。
