Bos Johannes L
Department of Physiological Chemistry and Centre for Biomedical Genetics, UMC Utrecht, Universiteitsweg 100, 3584CG Utrecht, The Netherlands.
Curr Opin Cell Biol. 2005 Apr;17(2):123-8. doi: 10.1016/j.ceb.2005.02.009.
The small GTPase Rap1 is involved in several aspects of cell adhesion, including integrin-mediated cell adhesion and cadherin-mediated cell junction formation. Recently, several effector proteins for Rap1 have been identified providing a clear link between Rap1 and actin dynamics. Furthermore, evidence is accumulating that Rap1 functions in the spatial and temporal control of cell polarity.
小GTP酶Rap1参与细胞黏附的多个方面，包括整合素介导的细胞黏附和钙黏蛋白介导的细胞连接形成。最近，已鉴定出几种Rap1的效应蛋白，它们在Rap1与肌动蛋白动力学之间建立了明确的联系。此外，越来越多的证据表明，Rap1在细胞极性的时空控制中发挥作用。
