Allen Matthew R, Burr David B
Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, MS-5035 Indianapolis, IN 46202, USA.
Bone. 2005 Feb;36(2):311-6. doi: 10.1016/j.bone.2004.10.013.
Periosteal expansion enhances bone strength and is controlled by osteogenic cells of the periosteum. The extent of cellular periosteum at the human femoral neck, a clinically relevant site, is unclear. This study was designed to histologically evaluate the human femoral neck periosteal surface. Femoral neck samples from 11 male and female cadavers (ages 34-88) were histologically assessed and four periosteal surface classifications (cellular periosteum, mineralizing periosteum, cartilage, and mineralizing cartilage) were quantified. Femoral mid-diaphysis samples from the same cadavers were used as within-specimen controls. The femoral neck surface had significantly less (P<0.05) cellular periosteum (18.4+/-9.7%) compared to the femoral diaphysis (59.2+/-13.8%). A significant amount of the femoral neck surface was covered by mineralizing periosteal tissue (20-70%). These data may provide an alternate explanation for the apparent femoral neck periosteal expansion with age and suggest the efficiency of interventions that stimulate periosteal expansion may be reduced, albeit still possible, at the femoral neck of humans.
骨膜扩张可增强骨强度，并受骨膜成骨细胞控制。在临床上具有重要意义的人类股骨颈处，细胞性骨膜的范围尚不清楚。本研究旨在对人类股骨颈骨膜表面进行组织学评估。对11具男性和女性尸体（年龄34 - 88岁）的股骨颈样本进行组织学评估，并对四种骨膜表面分类（细胞性骨膜、矿化骨膜、软骨和矿化软骨）进行定量分析。将同一尸体的股骨干中段样本用作样本内对照。与股骨干（59.2±13.8%）相比，股骨颈表面的细胞性骨膜显著较少（P<0.05）（18.4±9.7%）。大量股骨颈表面被矿化骨膜组织覆盖（20 - 70%）。这些数据可能为随着年龄增长股骨颈明显的骨膜扩张提供另一种解释，并表明在人类股骨颈处，刺激骨膜扩张的干预措施的效果可能会降低，尽管仍然可行。
