Danson Edward J, Choate Julia K, Paterson David J
University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, UK.
Pharmacol Ther. 2005 Apr;106(1):57-74. doi: 10.1016/j.pharmthera.2004.11.003. Epub 2005 Jan 26.
Emerging evidence shows that neuronal nitric oxide synthase (nNOS) plays several diverging roles in modulating cardiac function. This review examines the nitric oxide (NO) pathway and the regulatory mechanisms to which nNOS signalling is sensitive. These mechanisms are diverse and include regulation of gene expression, posttranscriptional regulation, protein trafficking, allosteric modulation of nNOS and redox modification to alter NO bioavailability once synthesised. Functionally, alteration in nNOS-NO signalling in the heart may correlate with different cardiac regulatory states. The idea of this being associated with exercise-trained states and myocardial disease is discussed.
新出现的证据表明，神经元型一氧化氮合酶（nNOS）在调节心脏功能方面发挥着多种不同的作用。本综述探讨了一氧化氮（NO）途径以及nNOS信号传导所敏感的调节机制。这些机制多种多样，包括基因表达调控、转录后调控、蛋白质运输、nNOS的变构调节以及氧化还原修饰，以在NO合成后改变其生物利用度。在功能上，心脏中nNOS-NO信号的改变可能与不同的心脏调节状态相关。本文还讨论了这与运动训练状态和心肌病相关的观点。
