硕大利什曼原虫可调节树突状细胞的趋化因子及其受体表达，并影响其迁移能力。
Leishmania major modulates chemokine and chemokine receptor expression by dendritic cells and affects their migratory capacity.
作者信息
Steigerwald Mario, Moll Heidrun
机构信息
Institut für Molekulare Infektionsbiologie, Universität Würzburg, Röntgenring 11, 97070 Würzburg, Germany.
出版信息
Infect Immun. 2005 Apr;73(4):2564-7. doi: 10.1128/IAI.73.4.2564-2567.2005.
Abstract
Dendritic cells (DC) both produce and respond to chemokines. We examined the profiles of chemokines and chemokine receptors expressed by DC and their chemotactic response after interaction with Leishmania major. Expression of the chemokine receptors CCR2 and CCR5 by DC and their responsiveness to the respective ligands, CCL2 and CCL3, were downregulated, while the level of CCR7 and the DC response to its ligand CCL21 were enhanced. These parasite-induced alterations were observed with DC from L. major-resistant and -susceptible mice. In contrast, expression of the chemokine CXCL10 was elicited only in DC from L. major-resistant mice.
摘要
树突状细胞（DC）既能产生趋化因子，也能对趋化因子产生反应。我们检测了DC表达的趋化因子和趋化因子受体的概况，以及它们与硕大利什曼原虫相互作用后的趋化反应。DC对趋化因子受体CCR2和CCR5及其各自配体CCL2和CCL3的反应性下调，而CCR7的水平及其对配体CCL21的DC反应增强。在来自对硕大利什曼原虫有抗性和易感性的小鼠的DC中均观察到这些寄生虫诱导的变化。相比之下，趋化因子CXCL10仅在来自对硕大利什曼原虫有抗性的小鼠的DC中表达。
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