Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Brazil.
Federal University of Bahia, Salvador, Brazil.
Front Immunol. 2019 Feb 22;10:227. doi: 10.3389/fimmu.2019.00227. eCollection 2019.
Dendritic cells (DC) are a diverse group of leukocytes responsible for bridging innate and adaptive immunity. Despite their functional versatility, DCs exist primarily in two basic functional states: immature and mature. A large body of evidence suggests that upon interactions with pathogens, DCs undergo intricate cellular processes that culminate in their activation, which is paramount to the orchestration of effective immune responses against a parasites. Herein we offer a concise review of the emerging hallmarks of DCs activation in leishmaniasis as well as a comprehensive discussion of the following underlying molecular events: DC- interaction, antigen uptake, costimulatory molecule expression, parasite ability to affect DC migration, antigen presentation, metabolic reprogramming, and epigenetic alterations.
树突状细胞（DC）是一群负责连接先天免疫和适应性免疫的白细胞。尽管它们具有多功能性，但 DC 主要存在于两种基本的功能状态：未成熟和成熟。大量证据表明，在与病原体相互作用后，DC 会经历复杂的细胞过程，最终导致其激活，这对于寄生虫的有效免疫反应的协调至关重要。在此，我们简要回顾了在利什曼病中 DC 激活的新特征，并全面讨论了以下潜在的分子事件：DC 相互作用、抗原摄取、共刺激分子表达、寄生虫影响 DC 迁移的能力、抗原呈递、代谢重编程和表观遗传改变。
