抗苗勒管激素：其在卵泡生长启动与存活中的作用以及作为卵巢储备标志物的作用。

Anti-Müllerian hormone: its role in follicular growth initiation and survival and as an ovarian reserve marker.

作者信息

Themmen Axel P N

机构信息

Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.

出版信息

J Natl Cancer Inst Monogr. 2005(34):18-21. doi: 10.1093/jncimonographs/lgi026.

DOI:10.1093/jncimonographs/lgi026

PMID:15784815

Abstract

In this paper the role in the ovary of anti-Müllerian hormone (AMH), a member of the transforming growth factor-beta family of growth and differentiation factors, is reviewed. AMH has an inhibitory effect on primordial follicle recruitment and may also inhibit follicle-stimulating homone-dependent selection of follicles for dominance. In addition to its functional role in the ovary, AMH in serum is an excellent candidate marker as an indication of the ovarian reserve, not only in infertility clinic patients but also in women during and after cancer treatment.

摘要

本文综述了转化生长因子-β生长和分化因子家族成员抗苗勒管激素（AMH）在卵巢中的作用。AMH对原始卵泡募集具有抑制作用，还可能抑制促卵泡激素依赖的优势卵泡选择。除了在卵巢中的功能作用外，血清中的AMH是一种极佳的候选标志物，可用于指示卵巢储备，不仅适用于不孕门诊患者，也适用于癌症治疗期间及之后的女性。