抗苗勒管激素：一种卵巢功能的新标志物。

Anti-Müllerian hormone: a new marker for ovarian function.

作者信息

Visser Jenny A, de Jong Frank H, Laven Joop S E, Themmen Axel P N

机构信息

Department of Internal Medicine, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands.

出版信息

Reproduction. 2006 Jan;131(1):1-9. doi: 10.1530/rep.1.00529.

DOI:10.1530/rep.1.00529

PMID:16388003

Abstract

Anti-Müllerian hormone (AMH) is a member of the transforming growth factor beta family of growth and differentiation factors. In the ovary, AMH has an inhibitory effect on primordial follicle recruitment as well as on the responsiveness of growing follicles to follicle-stimulating hormone (FSH). The ovary-specific expression pattern in granulosa cells of growing nonselected follicles makes AMH an ideal marker for the size of the ovarian follicle pool. This review summarizes recent findings concerning AMH and its role as a marker for the quantitative aspect of ovarian reserve as well as ovarian dysfunction.

摘要

抗苗勒管激素（AMH）是转化生长因子β家族中生长和分化因子的一员。在卵巢中，AMH对原始卵泡募集以及生长卵泡对促卵泡激素（FSH）的反应性具有抑制作用。生长中的未被选择卵泡的颗粒细胞中卵巢特异性表达模式使AMH成为卵巢卵泡池大小的理想标志物。本综述总结了关于AMH及其作为卵巢储备以及卵巢功能障碍定量方面标志物作用的最新研究结果。