高剂量左旋多巴治疗的帕金森病患者淋巴细胞中多巴胺含量增加。

Increased dopamine content in lymphocytes from high-dose L-Dopa-treated Parkinson's disease patients.

作者信息

Rajda Cecilia, Dibó Gyorgy, Vécsei László, Bergquist Jonas

机构信息

Department of Neurology, University of Szeged, Szeged, Hungary.

出版信息

Neuroimmunomodulation. 2005;12(2):81-4. doi: 10.1159/000083579.

DOI:10.1159/000083579

PMID:15785109

Abstract

OBJECTIVES

The intracellular (i.c.) content of dopamine and its metabolites was measured in the peripheral blood lymphocytes (PBLs) of Parkinson's disease (PD) patients and healthy controls.

METHODS

Catecholamine levels of PBLs were measured using capillary electrophoresis in healthy controls and PD patients receiving different doses of L-dihydroxyphenylalanine (L-Dopa).

RESULTS

Higher i.c. dopamine content was found in lymphocytes from PD patients receiving a high dose of L-Dopa (700 +/- 30 mg/day) as compared to lymphocytes from the healthy controls (p = 0.002) and from PD patients treated with a low dose of L-Dopa (400 +/- 30 mg/day) (p = 0.022). The dihydroxyphenylacetic acid to dopamine ratio was significantly lower in the high-dose L-Dopa-treated PD patients than in the controls (p = 0.013).

CONCLUSIONS

These findings suggest that the dopamine content and metabolism in the peripheral lymphocytes of PD patients are influenced by L-Dopa administration. This is the first study in which a dose-related effect of L-Dopa treatment was found in lymphocytes from PD patients.

摘要

目的

测定帕金森病（PD）患者和健康对照者外周血淋巴细胞（PBLs）中多巴胺及其代谢产物的细胞内（i.c.）含量。

方法

使用毛细管电泳法测定健康对照者以及接受不同剂量左旋多巴（L-多巴）治疗的PD患者的PBLs中儿茶酚胺水平。

结果

与健康对照者（p = 0.002）以及接受低剂量L-多巴（400 ± 30 mg/天）治疗的PD患者的淋巴细胞相比，接受高剂量L-多巴（700 ± 30 mg/天）治疗的PD患者的淋巴细胞中i.c.多巴胺含量更高（p = 0.022）。高剂量L-多巴治疗的PD患者中，二羟基苯乙酸与多巴胺的比值显著低于对照组（p = 0.013）。