Department of Neurology, Iwate Medical University, 19-1 Uchimaru, Morioka, Iwate 020-0805, Japan.
J Clin Neurosci. 2010 Jun;17(6):717-21. doi: 10.1016/j.jocn.2009.09.034. Epub 2010 Mar 30.
To investigate the effect of L-3,4-dihydroxyphenylalanine (L-dopa) therapy on homocysteine (HC) concentration in patients with Parkinson's disease (PD), the concentrations in cerebrospinal fluid (CSF) of total HC and methionine (Met) were compared between 18 patients with PD before and after treatment with L-dopa and 16 neurologically normal control patients. Concentrations of total HC in patients with PD were significantly higher following L-dopa therapy (169+/-27 nM) than before treatment (111+/-22 nM) and than in controls (85+/-25 nM) (patients with PD before L-dopa treatment vs. controls, p<0.005; patients with PD after L-dopa treatment vs. before treatment, p<0.0001). Conversely, concentrations of total Met in patients with PD were significantly lower after L-dopa therapy (5.3+/-1.7 microM) than before L-dopa therapy (6.8+/-1.9 microM) (p<0.001). These findings in patients with PD suggest that L-dopa therapy enhances intracerebral methylation and elevates concentration of HC.
为了研究 L-3,4-二羟基苯丙氨酸（L-dopa）治疗对帕金森病（PD）患者同型半胱氨酸（HC）浓度的影响，我们比较了 18 例接受 L-dopa 治疗前后 PD 患者和 16 例神经正常对照患者脑脊液（CSF）中总 HC 和蛋氨酸（Met）的浓度。与治疗前（111±22 nM）和对照组（85±25 nM）相比，PD 患者经 L-dopa 治疗后总 HC 浓度显著升高（169±27 nM）（PD 患者治疗前 vs. 对照组，p<0.005；PD 患者治疗后 vs. 治疗前，p<0.0001）。相反，PD 患者经 L-dopa 治疗后总 Met 浓度显著降低（5.3±1.7 microM）（治疗前 vs. 治疗后，p<0.001）。这些 PD 患者的发现表明，L-dopa 治疗增强了脑内甲基化并升高了 HC 浓度。
