Fujiwara M, Soga N, Kurokawa I
Department of Internal Medicine, Nagaoka Red Cross Hospital.
Rinsho Ketsueki. 1992 Mar;33(3):377-83.
We report a patient with systemic plasmacytosis with polyclonal hyperimmunoglobulinemia who at presentation showed a blood and bone marrow picture suggestive of plasma cell leukemia. A 78-year-old woman was admitted to our hospital because of marked hepatosplenomegaly and generalized lymphadenopathy. She had leukocytosis with 42% plasmacytes, and plasma cells were increased also in her bone marrow (32.6%). She had marked polyclonal hyperimmunoglobulinemia with increased IgG, IgA and IgE. IgM and IgD were normal. She complained of cough and dyspnea. Her general condition was too poor to remove a lymph node for pathological examination. After treatment with daunorubicin, vincristine and prednisolone (DVP), her lymphadenopathy diminished rapidly, the immunoglobulins decreased and the plasma cells in her blood disappeared. She achieved a complete remission and has been in good condition without further treatment for 24 months.
我们报告一例患有系统性浆细胞增多症伴多克隆高免疫球蛋白血症的患者，其初诊时血液和骨髓检查结果提示浆细胞白血病。一名78岁女性因明显的肝脾肿大和全身淋巴结肿大入住我院。她存在白细胞增多，浆细胞占42%，骨髓中浆细胞也增多（32.6%）。她有明显的多克隆高免疫球蛋白血症，IgG、IgA和IgE升高。IgM和IgD正常。她主诉咳嗽和呼吸困难。她的一般状况太差，无法切除淋巴结进行病理检查。在用柔红霉素、长春新碱和泼尼松龙（DVP）治疗后，她的淋巴结肿大迅速减轻，免疫球蛋白降低，血液中的浆细胞消失。她实现了完全缓解，且在未进一步治疗的情况下状况良好达24个月。
