Gassaye D, Atipo Ibara B I, Ndolo-Mpika A B, Ibara J R, Okouo M, Ossendza R A, Ngoma-Mambouana Ph, Itoua-Ngaporo A
Service de gastro-entérologie et médecine interne, CHU, BP 32, Brazzaville, Congo.
Bull Soc Pathol Exot. 2004;97(5):323-4.
Authors relate a retrospective survey of 140 cases of digestive haemorrhage after intake of anti-inflammatory drugs from January 1988 to December 2000. The digestive haemorrhage frequency after intake of anti-inflammatory drugs reaches 16%. This survey included 94 men and 46 women whose average age is 42.3 years, with extremes of 15 and 79 years. Among these patients, 75 took salicylic acetyl acid (SAA), 56 non-steroidal anti-inflammatory drug (NSAID) and 9 the SAA and NSAID association. More than half of patients relied on self-medication (91 cases ie. 65%). The haematemesis followed by melaena induced the most frequent bleeding (42.8% of cases), while the isolated haematemesis, the isolated melaena and the isolated rectal haemorrhage were found respectively in 35%, 15% and 7.2%. Haemorrhages occur early under SAA and seem less severe than those occurring under NSAID. Lesions responsible for the bleeding are: the duodenal ulcer (68.7%), the haemorrhagic gastritis (6.4%), the gastric ulcer (5%), the oesophagitis (4.2%), the gastric and duodenal ulcer association (3.5%), anorectal exsudative pains and haemorrhagic anal ulcerations. The duodenal ulcer predominance could be attributed to previous lesions.
作者报告了一项对1988年1月至2000年12月期间140例服用抗炎药后发生消化性出血病例的回顾性调查。服用抗炎药后消化性出血的发生率达16%。该调查包括94名男性和46名女性，平均年龄为42.3岁，年龄范围在15岁至79岁之间。这些患者中，75人服用了乙酰水杨酸（SAA），56人服用了非甾体抗炎药（NSAID），9人同时服用了SAA和NSAID。超过半数的患者自行用药（91例，即65%）。呕血继之以黑便引发的出血最为常见（占病例的42.8%），而单纯呕血、单纯黑便和单纯直肠出血分别占35%、15%和7.2%。SAA导致的出血出现较早，且似乎不如NSAID导致的出血严重。引起出血的病变有：十二指肠溃疡（68.7%）、出血性胃炎（6.4%）、胃溃疡（5%）、食管炎（4.2%）、胃和十二指肠溃疡并存（3.5%）、肛门直肠渗出性疼痛和出血性肛门溃疡。十二指肠溃疡占主导可能归因于既往病变。
