无需使用保护基团即可快速构建 vibsanin E 核心结构。

Expedient construction of the vibsanin E core without the use of protecting groups.

作者信息

Heim Ralf, Wiedemann Stefan, Williams Craig M, Bernhardt Paul V

机构信息

School of Molecular and Microbial Sciences, University of Queensland, St. Lucia, 4072 Queensland, Australia.

出版信息

Org Lett. 2005 Mar 31;7(7):1327-9. doi: 10.1021/ol0501222.

DOI:10.1021/ol0501222

PMID:15787498

Abstract

[reaction: see text] The tricyclic core of vibsanin E was constructed without the use of a protecting group in six steps. The El Gaïed Baylis-Hillman variant was key to allowing the Brønsted acid induced tandem cyclization forming rings B and C in one operation.

摘要

[反应：见正文] 卫矛宁E的三环核心在不使用保护基团的情况下经六步构建而成。埃尔盖德贝利斯-希尔曼变体是实现布朗斯特酸诱导串联环化一步形成B环和C环的关键。