Roy Nilmadhab, Das Rishav, Paira Rupankar, Paira Priyankar
Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology Vellore 632014 Tamilnadu India
Department of Chemistry, Maharaja Manindra Chandra College 20 Ramkanto Bose Street Kolkata 700 003 India
RSC Adv. 2023 Jul 25;13(32):22389-22480. doi: 10.1039/d3ra02003g. eCollection 2023 Jul 19.
Cancer is the second most high-morbidity disease throughout the world. From ancient days, natural products have been known to possess several biological activities, and research on natural products is one of the most enticing areas where scientists are engrossed in the extraction of valuable compounds from various plants to isolate many life-saving medicines, along with their other applications. It has been noticed that the bicyclo[3.3.1]nonane moiety is predominant in most biologically active natural products owing to its exceptional characteristics compared to others. Many derivatives of bicyclo[3.3.1]nonane are attractive to researchers for use in asymmetric catalysis or as potent anticancer entities along with their successful applications as ion receptors, metallocycles, and molecular tweezers. Therefore, this review article discusses several miscellaneous synthetic routes for the construction of bicyclo[3.3.1]nonanes and their heteroanalogues in association with the delineation of their anticancer activities with few selective compounds.
癌症是全球第二高发病率的疾病。自古以来，天然产物就被认为具有多种生物活性，对天然产物的研究是最具吸引力的领域之一，科学家们热衷于从各种植物中提取有价值的化合物，以分离出许多救命药物以及它们的其他应用。人们已经注意到，双环[3.3.1]壬烷部分在大多数生物活性天然产物中占主导地位，因为与其他部分相比，它具有特殊的特性。双环[3.3.1]壬烷的许多衍生物因其在不对称催化中的应用、作为有效的抗癌实体以及作为离子受体、金属环和分子镊子的成功应用而吸引了研究人员。因此，这篇综述文章讨论了几种构建双环[3.3.1]壬烷及其杂类似物的各种合成路线，并描述了它们对少数选择性化合物的抗癌活性。
