Hagenbeek A
Institute of Applied Radiobiology and Immunology TNO, Rijswijk, The Netherlands.
Leukemia. 1992;6 Suppl 2:12-6.
Recent achievements in decreasing the detection level of "minimal residual disease" in leukemia are summarized both in a relevant rat model for acute myelocytic leukemia (BNML) and in the human leukemias. Detection levels as low as 1 leukemic cell per 10(8)-10(9) and 10(5)-10(6) normal bone marrow cells have become realistic in the animal model and in human leukemia, respectively. The implications of these new tools for detecting hidden leukemic cells are discussed.
本文总结了在降低白血病“微小残留病”检测水平方面的最新成果，这些成果既体现在急性髓细胞白血病相关大鼠模型（BNML）中，也体现在人类白血病研究中。在动物模型和人类白血病中，分别已实现低至每10⁸ - 10⁹个正常骨髓细胞中有1个白血病细胞以及每10⁵ - 10⁶个正常骨髓细胞中有1个白血病细胞的检测水平。本文还讨论了这些检测隐藏白血病细胞新工具的意义。
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