自然杀伤细胞淋巴瘤的诊断线索：原发性淋巴结表现以及爱泼斯坦-巴尔病毒编码的早期小RNA原位杂交在检测隐匿性骨髓受累中的作用。
Diagnostic cues for natural killer cell lymphoma: primary nodal presentation and the role of in situ hybridisation for Epstein-Barr virus encoded early small RNA in detecting occult bone marrow involvement.
作者信息
Chim C-S, Ma E S K, Loong F, Kwong Y-L
机构信息
University Department of Medicine, Queen Mary Hospital, Pokfulam Road, Hong Kong, China.
出版信息
J Clin Pathol. 2005 Apr;58(4):443-5. doi: 10.1136/jcp.2004.022608.
Abstract
Natural killer (NK) cell lymphomas are rare, and atypical features might lead to diagnostic pitfalls. This report describes an unusual patient in whom lymphoma occurred initially as isolated lymph node involvement, an exceptional presentation of an almost exclusively extranodal disease. Furthermore, during the terminal haemophagocytosis in the bone marrow, lymphoma cells lost the expression of the NK cell marker, CD56, making the histopathological diagnosis of bone marrow involvement difficult. This was resolved by in situ hybridisation for Epstein-Barr virus encoded small RNA, which detected occult bone marrow infiltration.
摘要
自然杀伤（NK）细胞淋巴瘤较为罕见，其非典型特征可能导致诊断陷阱。本报告描述了一名特殊患者，其淋巴瘤最初表现为孤立性淋巴结受累，这是一种几乎仅发生于结外的疾病的罕见表现。此外，在骨髓终末期噬血细胞增多症期间，淋巴瘤细胞丧失了NK细胞标志物CD56的表达，使得骨髓受累的组织病理学诊断变得困难。通过对爱泼斯坦-巴尔病毒编码的小RNA进行原位杂交解决了这一问题，该方法检测到了隐匿性骨髓浸润。
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