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胰管支架置入术在慢性胰腺炎治疗中的作用。

Role of pancreatic duct stenting in the treatment of chronic pancreatitis.

作者信息

Vitale G C, Cothron K, Vitale E A, Rangnekar N, Zavaleta C M, Larson G M, Binford J, Hammond B

机构信息

Department of Surgery, University of Louisville and the Center for Advanced Surgical Technologies, Louisville, KY 40292, USA.

出版信息

Surg Endosc. 2004 Oct;18(10):1431-4. doi: 10.1007/s00464-003-8933-z. Epub 2004 Aug 26.

Abstract

BACKGROUND

Endoscopic retrograde cholangiopancreatography and stent placement are relatively new alternatives to surgery for the treatment of chronic pancreatitis. The objective of this study was to determine the efficacy of pancreatic duct stent placement for the treatment of chronic pancreatitis.

METHODS

This study included 89 patients treated with pancreatic stents between 1993 and 2002. The patients were contacted via telephone for a personal interview with regard to pain, medication usage, weight loss or gain, and eating patterns. Additionally, medication usage before and after treatment was documented from the Kentucky Cabinet for Health Services' electronic reporting system for narcotic use.

RESULTS

Of the 89 patients, 9 were deceased, 5 either refused to interview or could not be contacted, and 75 were interviewed. Significant weight gain exceeding 15 lb after treatment was experienced by 22%, whereas only 4% lost weight. A majority of the patients (68%) noted that they had less severe relapses or no relapses after treatment. The patients reported a decrease in pain level on a 10-point scale from 8.7 to 4.1 (53% decrease) after treatment. A decrease in pain medication usage was reported by 47% of the patients, and 83% considered their treatment successful. The Kentucky All Schedule Prescription Electronic Report (KASPER) was obtained before and after treatment for 55 patients. According to this statewide electronic reporting system, 63% had a documented decrease in narcotic use.

CONCLUSION

The findings of this study support the use of pancreatic duct stenting as an option before surgical intervention for these difficult-to-manage patients with chronic pancreatitis.

摘要

背景

内镜逆行胰胆管造影术及支架置入术是治疗慢性胰腺炎的相对较新的手术替代方法。本研究的目的是确定胰管支架置入术治疗慢性胰腺炎的疗效。

方法

本研究纳入了1993年至2002年间接受胰管支架治疗的89例患者。通过电话联系患者进行个人访谈,内容涉及疼痛、药物使用、体重减轻或增加以及饮食模式。此外,从肯塔基州卫生服务部的麻醉药品使用电子报告系统中记录治疗前后的药物使用情况。

结果

89例患者中,9例死亡,5例拒绝访谈或无法联系到,75例接受了访谈。22%的患者在治疗后体重显著增加超过15磅,而只有4%的患者体重减轻。大多数患者(68%)指出治疗后复发症状减轻或未复发。患者报告治疗后疼痛程度从10分制的8.7分降至4.1分(降低了53%)。47%的患者报告止痛药使用量减少,83%的患者认为治疗成功。为55例患者获取了治疗前后的肯塔基州全处方电子报告(KASPER)。根据这个全州范围的电子报告系统,63%的患者有麻醉药品使用量减少的记录。

结论

本研究结果支持对于这些难以治疗的慢性胰腺炎患者,在手术干预前可选择胰管支架置入术。

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