寒冷暴露对大鼠肝脏和骨骼肌线粒体能量效率的影响不同。
Cold exposure differently influences mitochondrial energy efficiency in rat liver and skeletal muscle.
作者信息
Mollica Maria Pina, Lionetti Lillà, Crescenzo Raffaella, Tasso Rosaria, Barletta Antonio, Liverini Giovanna, Iossa Susanna
机构信息
Department of Biological Sciences, Section of Physiology, University of Naples "Federico II", Via Mezzocannone 8, I-80134 Naples, Italy.
出版信息
FEBS Lett. 2005 Mar 28;579(9):1978-82. doi: 10.1016/j.febslet.2005.02.044.
This study deals with mitochondrial energy efficiency in liver and skeletal muscle mitochondria in 15 days cold exposed rats. Cold exposure strongly increases the sensitivity to uncoupling by added palmitate of skeletal muscle but not liver mitochondria, while mitochondrial energy coupling in the absence of fatty acids is only slightly affected by cold in liver and skeletal muscle. In addition, uncoupling protein 3 content does not follow changes in skeletal muscle mitochondrial coupling. It is therefore concluded that skeletal muscle could play a direct thermogenic role based on fatty acid-induced mild uncoupling of mitochondrial oxidative phosphorylation.
本研究探讨了暴露于寒冷环境15天的大鼠肝脏和骨骼肌线粒体中的线粒体能量效率。寒冷暴露显著增加了骨骼肌线粒体对添加棕榈酸解偶联的敏感性，但对肝脏线粒体无此影响，而在没有脂肪酸的情况下，肝脏和骨骼肌线粒体的能量偶联仅受到寒冷的轻微影响。此外，解偶联蛋白3的含量并不随骨骼肌线粒体偶联的变化而变化。因此得出结论，骨骼肌可能基于脂肪酸诱导的线粒体氧化磷酸化轻度解偶联而发挥直接的产热作用。
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