白藜芦醇可挽救线虫和哺乳动物神经元中的突变型多聚谷氨酰胺细胞毒性。
Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons.
作者信息
Parker J Alex, Arango Margarita, Abderrahmane Salima, Lambert Emmanuel, Tourette Cendrine, Catoire Hélène, Néri Christian
机构信息
Institut National de la Santé et de la Recherche Médicale, Avenir Group, Laboratory of Genomic Biology, Centre Paul Broca, 75014 Paris, France.
出版信息
Nat Genet. 2005 Apr;37(4):349-50. doi: 10.1038/ng1534. Epub 2005 Mar 27.
We report that Sir2 activation through increased sir-2.1 dosage or treatment with the sirtuin activator resveratrol specifically rescued early neuronal dysfunction phenotypes induced by mutant polyglutamines in transgenic Caenorhabditis elegans. These effects are dependent on daf-16 (Forkhead). Additionally, resveratrol rescued mutant polyglutamine-specific cell death in neuronal cells derived from HdhQ111 knock-in mice. We conclude that Sir2 activation may protect against mutant polyglutamines.
我们报告称，通过增加sir-2.1剂量或用sirtuin激活剂白藜芦醇处理来激活Sir2，可特异性挽救转基因秀丽隐杆线虫中由突变多聚谷氨酰胺诱导的早期神经元功能障碍表型。这些效应依赖于daf-16（叉头框蛋白）。此外，白藜芦醇挽救了源自HdhQ111基因敲入小鼠的神经元细胞中的突变多聚谷氨酰胺特异性细胞死亡。我们得出结论，Sir2激活可能对突变多聚谷氨酰胺具有保护作用。
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