Kuzmanović Ilija B, Davidović Lazar B, Kostić Dusan M, Maksimović Zivan L, Cinara Ilijas S, Svetković Slobodan D, Marković Dragan M, Moarković Miroslav M, Krstić Nevena, Koncar Igor B
Srp Arh Celok Lek. 2004 Sep-Oct;132(9-10):306-12. doi: 10.2298/sarh0410306k.
Abdominal aortic aneurysm can be repaired by elective procedure while asymptomatic, or immediately when it is complicated--mostly due to rupture. Treating abdominal aneurysm electively, before it becomes urgent, has medical and economical reason. Today, the first month mortality after elective operations of the abdominal aorta aneurysm is less than 3%; on the other hand, significant mortality (25%-70%) has been recorded in patients operated immediately because of rupture of the abdominal aneurysm. In addition, the costs of elective surgical treatment are significantly lower.
The objective of this study is to compare long-term survival of patients that underwent elective or immediate repair of abdominal aortic aneurysm (due to rupture), and to find out the factors influencing the long-term survival of these patients.
Through retrospective review of prospectively collected data of the Institute for Cardiovascular Diseases of Clinical Center of Serbia, Belgrade, 56 patients that had elective surgery and 35 patients that underwent urgent operation due to rupture of abdominal aneurysm were followed up. Only the patients that survived 30 postoperative days were included in this review, and-were followed up (ranging from 2 to 126 months). Electively operated patients were followed during 58.82 months on the average (range 7 to 122), and urgently operated were followed over 52.26 months (range 2 to 126). There was no significant difference of the length of postoperative follow-up between these two groups.
During this period, out of electively operated and immediately operated patients, 27 and 22 cases died, respectively. There was no significant difference (p>0.05a) of long-term survival between these two groups. Obesity and early postoperative complications significantly decreased long-term survival of both electively and immediately operated patients. Graft infection, ventral hernia, aneurysm of peripheral arteries and other vascular reconstructive procedures were the factors that significantly reduced long-term survival of patients operated immediately due to rupture.
This comprehensive study has searched for more factors than others had done before. The applied discriminative analysis numerically evaluated the influence of any risk factor of mortality. These factors were divided in three groups as follows: preoperative, operative and postoperative ones. Preoperative factors were sex, age, diabetes mellitus, arterial hypertension, obesity, COPD, and naturally, the indication for operative treatment of ruptured or non-ruptured abdominal aneurysm. Among all these factors, only obesity significantly reduced long-term survival of electively operated patients. It may be said that immediately operated patients who survived the first 30 postoperative days had quite good long-term survival. Operative factors such as type of operative procedure and vascular graft had no influence on long-term survival of patients in both groups. Postoperative risk factors were early postoperative complications, graft infection, symptomatic cerebrovascular disease, carotid endarterectomy, myocardial revascularization, ventral hernias, "other" non vascular operations, malignancy, mental disorders, peripheral aneurysms and occlusive vascular disease, and other vascular operations either due to aneurysm or peripheral occlusive disease. Early postoperative complications (even graft infection) had no significant effect on long-term survival. Ventral hernias and peripheral aneurysms were factors that significantly decreased long-term survival of patients operated for rupture of the abdominal aneurysm.
It is interesting that endarterectomy, myocardial revascularization or malignancy after repair of the abdominal aneurysm (ruptured or non-ruptured) had no effect on long-term survival.
腹主动脉瘤可在无症状时通过择期手术修复,或在出现并发症(主要是破裂)时立即进行修复。在腹主动脉瘤变得紧急之前进行择期治疗,有医学和经济方面的原因。如今,腹主动脉瘤择期手术后的首月死亡率低于3%;另一方面,因腹主动脉瘤破裂而立即接受手术的患者死亡率显著(25%-70%)。此外,择期手术治疗的费用要低得多。
本研究的目的是比较接受腹主动脉瘤择期或急诊修复(因破裂)患者的长期生存率,并找出影响这些患者长期生存的因素。
通过回顾性分析塞尔维亚贝尔格莱德临床中心心血管病研究所前瞻性收集的数据,对56例行择期手术的患者和35例因腹主动脉瘤破裂接受急诊手术的患者进行随访。本综述仅纳入术后存活30天的患者,并对其进行随访(随访时间为2至126个月)。择期手术患者平均随访58.82个月(范围7至122个月),急诊手术患者平均随访52.26个月(范围2至126个月)。两组术后随访时间长度无显著差异。
在此期间,择期手术和急诊手术患者分别有27例和22例死亡。两组患者的长期生存率无显著差异(p>0.05)。肥胖和术后早期并发症显著降低了择期手术和急诊手术患者的长期生存率。移植物感染、腹侧疝、外周动脉动脉瘤及其他血管重建手术是因破裂而急诊手术患者长期生存率显著降低的因素。
这项综合性研究比以往的研究探寻了更多因素。所应用的判别分析从数值上评估了任何死亡风险因素的影响。这些因素分为以下三组:术前、术中及术后因素。术前因素包括性别、年龄、糖尿病、动脉高血压、肥胖、慢性阻塞性肺疾病,当然还有破裂或未破裂腹主动脉瘤手术治疗的指征。在所有这些因素中,只有肥胖显著降低了择期手术患者的长期生存率。可以说,术后存活前30天的急诊手术患者长期生存率相当不错。手术方式和血管移植物等手术因素对两组患者的长期生存率均无影响。术后风险因素包括术后早期并发症、移植物感染、有症状的脑血管疾病、颈动脉内膜切除术、心肌血运重建、腹侧疝、“其他”非血管手术、恶性肿瘤、精神障碍、外周动脉瘤和闭塞性血管疾病,以及因动脉瘤或外周闭塞性疾病进行的其他血管手术。术后早期并发症(甚至移植物感染)对长期生存率无显著影响。腹侧疝和外周动脉瘤是因腹主动脉瘤破裂接受手术患者长期生存率显著降低的因素。
有趣的是,腹主动脉瘤(破裂或未破裂)修复术后的内膜切除术、心肌血运重建或恶性肿瘤对长期生存率没有影响。