He Z-H, Ma L-H
China Institute of Sports Science, Beijing, PR China.
Int J Sports Med. 2005 May;26(4):253-7. doi: 10.1055/s-2004-821009.
The purpose of the study was to compare the aerobic fitness (VO (2) peak) between obese and non-obese boys at pre-puberty and examine the effect of body composition on VO (2) peak in this cohort with reference to TaqI polymorphism at alpha-fibrinogen gene locus. Seventy-seven Chinese boys with similar lifestyle participated in the study. Among them, 47 were diagnosed as obese. VO (2) peak was measured by a treadmill test and body composition was assessed via a combined anthropometrical and bioelectrical impedance analysis method. The alpha-fibrinogen genetic polymorphism was detected through PCR-based digestion with TaqI restriction enzyme. The results indicated that VO (2) peak was significantly lower in obese boys compared with normal weight counterparts when the data were expressed either in conventional ratio unit (ml (-1) . min (-1) . lean body weight [LBW] (-1)) or in allometric unit (ml (-1) . min (-1) . body weight [BW] (-2/3)). LBW, fat mass (FM), and body fat content (BF %) all were correlated with VO (2) peak, while LBW was the strongest predictor. The relationship between body composition and VO (2) peak seemed quite comparable across different alpha-fibrinogen genotypes. Significant difference was observed between obese and non-obese boys in terms of the proportion of genotypes and frequency of alleles. T1T1 homozygotes had higher risk for obesity. We came to the conclusion that prepubertal obese boys exhibited impaired aerobic fitness compared with their normal weight peers. VO (2) peak is closely related to LBW and independent of FM. This relationship remains constant irrespective of the TaqI alpha-fibrinogen genotypes that may be associated with fatness in boys.
本研究的目的是比较青春期前肥胖和非肥胖男孩的有氧适能（VO₂峰值），并参照α-纤维蛋白原基因座的TaqI多态性，研究该队列中身体成分对VO₂峰值的影响。77名生活方式相似的中国男孩参与了本研究。其中，47名被诊断为肥胖。通过跑步机测试测量VO₂峰值，并通过人体测量和生物电阻抗分析相结合的方法评估身体成分。通过基于PCR的TaqI限制酶消化检测α-纤维蛋白原基因多态性。结果表明，当数据以常规比率单位（ml⁻¹·min⁻¹·去脂体重[LBW]⁻¹）或体表面积单位（ml⁻¹·min⁻¹·体重[BW]⁻²/³）表示时，肥胖男孩的VO₂峰值显著低于正常体重的男孩。LBW、脂肪量（FM）和体脂含量（BF%）均与VO₂峰值相关，而LBW是最强的预测因子。不同α-纤维蛋白原基因型之间，身体成分与VO₂峰值的关系似乎相当类似。在肥胖和非肥胖男孩之间，观察到基因型比例和等位基因频率存在显著差异。T1T1纯合子患肥胖症的风险更高。我们得出的结论是，青春期前肥胖男孩与正常体重的同龄人相比，有氧适能受损。VO₂峰值与LBW密切相关，且独立于FM。无论TaqIα-纤维蛋白原基因型如何，这种关系都保持不变，而该基因型可能与男孩的肥胖有关。
