Faussillon Marine, Monnier Lucie, Junien Claudine, Jeanpierre Cécile
INSERM U383, Hôpital Necker-Enfants Malades, Université René Descartes, 149-161 rue de Sèvres, 75743 Paris Cedex 15, France.
Cancer Lett. 2005 Apr 18;221(1):67-75. doi: 10.1016/j.canlet.2004.08.010.
The expression status of the three cyclin D genes (CCND1, CCND2 and CCND3), the two cyclin D-dependent kinase genes (CDK4 and CDK6) and the p16(INK4a) gene was studied in a series of 47 Wilms' tumors, 16 normal mature kidneys and two fetal kidneys. We showed predominant overexpression of CCND2 and CDK4 compared to CCND1/D3 and CDK6 respectively. We found a specific correlation between relapse and CDK4 overexpression, but not CDK6 overexpression. We did not identify any methylation of the p16(INK4a) promoter. This suggests that dysregulation of CCND2 and CDK4 plays a specific role in WT tumorigenesis.
在47例肾母细胞瘤、16例正常成熟肾脏和2例胎儿肾脏中，研究了三种细胞周期蛋白D基因（CCND1、CCND2和CCND3）、两种细胞周期蛋白D依赖性激酶基因（CDK4和CDK6）以及p16(INK4a)基因的表达状态。我们发现，与CCND1/D3和CDK6相比，CCND2和CDK4分别呈主要过表达。我们发现复发与CDK4过表达之间存在特定相关性，但与CDK6过表达无关。我们未发现p16(INK4a)启动子有任何甲基化现象。这表明CCND2和CDK4的失调在肾母细胞瘤的肿瘤发生中起特定作用。
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