Rhee Mary K, Slocum Wrenn, Ziemer David C, Culler Steven D, Cook Curtiss B, El-Kebbi Imad M, Gallina Daniel L, Barnes Catherine, Phillips Lawrence S
The Division of Endocrinology and Metabolism, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia (Drs Rhee, Ziemer, Cook, El-Kebbi, Gallina, Barnes, Phillips)
The Strategic National Stockpile Program, Program Preparedness Branch, the Centers for Chronic Disease Control and Health Prevention, Atlanta, Georgia (Mr Slocum)
Diabetes Educ. 2005 Mar-Apr;31(2):240-50. doi: 10.1177/0145721705274927.
The purpose of this study was to assess the influence of appointment keeping and medication adherence on HbA1c.
A retrospective evaluation was performed in 1560 patients with type 2 diabetes who presented for a new visit to the Grady Diabetes Clinic between 1991 and 2001 and returned for a follow-up visit and HbA1c after 1 year of care. Appointment keeping was assessed by the number of scheduled intervening visits that were kept, and medication adherence was assessed by the percentage of visits in which self-reported diabetes medication use was as recommended at the preceding visit.
The patients had an average age of 55 years, body mass index (BMI) of 32 kg/m2, diabetes duration of 4.6 years, and baseline HbA1c of 9.1%. Ninety percent were African American, and 63% were female. Those who kept more intervening appointments had lower HbA1c levels after 12 months of care (7.6% with 6-7 intervening visits vs 9.7% with 0 intervening visits). Better medication adherence was also associated with lower HbA1c levels after 12 months of care (7.8% with 76%-100% adherence). After adjusting for age, gender, race, BMI, diabetes duration, and diabetes therapy in multivariate linear regression analysis, the benefits of appointment keeping and medication adherence remained significant and contributed independently; the HbA1c was 0.12% lower for every additional intervening appointment that was kept (P = .0001) and 0.34% lower for each quartile of better medication adherence (P = .0009).
Keeping more appointments and taking diabetes medications as directed were associated with substantial improvements in HbA1c. Efforts to enhance glycemic outcomes should include emphasis on these simple but critically important aspects of patient adherence.
本研究旨在评估按时就诊和药物依从性对糖化血红蛋白(HbA1c)的影响。
对1991年至2001年间首次到格雷迪糖尿病诊所就诊、并在接受1年治疗后返回进行随访及检测HbA1c的1560例2型糖尿病患者进行回顾性评估。按时就诊情况通过实际就诊的预定中间就诊次数进行评估,药物依从性通过自我报告的糖尿病药物使用情况与上次就诊建议相符的就诊次数百分比进行评估。
患者的平均年龄为55岁,体重指数(BMI)为32kg/m²,糖尿病病程为4.6年,基线HbA1c为9.1%。90%为非裔美国人,63%为女性。在接受12个月治疗后,按时就诊次数较多的患者HbA1c水平较低(6 - 7次中间就诊的患者为7.6%,0次中间就诊的患者为9.7%)。更好的药物依从性也与12个月治疗后的较低HbA1c水平相关(依从性为76% - 100%的患者为7.8%)。在多因素线性回归分析中,对年龄、性别、种族、BMI、糖尿病病程和糖尿病治疗进行校正后,按时就诊和药物依从性的益处仍然显著且独立起作用;每多按时就诊一次,HbA1c降低0.12%(P = 0.0001),药物依从性每提高一个四分位数,HbA1c降低0.34%(P = 0.0009)。
增加就诊次数并按医嘱服用糖尿病药物与HbA1c的显著改善相关。为改善血糖结果所做的努力应包括强调患者依从性这些简单但至关重要的方面。