Kim B K, Kim D, Cho S H, Yuk S H
Department of Polymer Science and Engineering, Hannam University, Daedeog Ku, Taejeon, Korea 306-791.
J Microencapsul. 2004 Nov;21(7):697-707. doi: 10.1080/02652040400000520.
A novel method for preparing the PLGA nanospheres with hydrophilic surface has been designed and characterized. Because of good solubility of tetraglycol in water, PLGA (poly(lactide-co-glycolide)) nanospheres were formed by spraying the PLGA/tetraglycol solution into water. The size of PLGA nanospheres was manipulated by changing the concentration of PLGA/tetraglycol solution. Based on the hydrophobic interaction between PLGA and poly(propylene oxide) domain of F-127 (one of Pluronics, poly(ethylene oxide)-poly(propylene oxide)poly(ethylene oxide) triblock copolymer, F-127-coated PLGA nanospheres was prepared to enhance the stability of PLGA nanospheres in the aqueous media. For the application as a drug delivery vehicle, it was characterized by measuring the loading amount, the encapsulation efficiency and the release pattern of drug. Paclitaxel used as a potent anti-cancer drug was selected as a model drug.
一种制备具有亲水性表面的聚乳酸-羟基乙酸共聚物（PLGA）纳米球的新方法已被设计并表征。由于四甘醇在水中具有良好的溶解性，通过将PLGA/四甘醇溶液喷入水中形成了PLGA纳米球。通过改变PLGA/四甘醇溶液的浓度来控制PLGA纳米球的尺寸。基于PLGA与F-127（一种泊洛沙姆，聚环氧乙烷-聚环氧丙烷-聚环氧乙烷三嵌段共聚物）的聚环氧丙烷域之间的疏水相互作用，制备了F-127包被的PLGA纳米球，以提高PLGA纳米球在水性介质中的稳定性。作为药物递送载体应用时，通过测量药物的负载量、包封率和释放模式对其进行了表征。选择强力抗癌药物紫杉醇作为模型药物。
