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2%利多卡因凝胶在翼状胬肉手术中的疗效

Efficacy of lidocaine 2% gel in pterygium surgery.

作者信息

Oksuz H, Tamer C

机构信息

Department of Ophthalmology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.

出版信息

Acta Ophthalmol Scand. 2005 Apr;83(2):206-9. doi: 10.1111/j.1600-0420.2005.00404.x.

Abstract

PURPOSE

Anaesthesia during pterygium surgery is usually achieved with local injection of anaesthetic medications. The aim of this study was to determine whether lidocaine 2% gel is an effective topical anaesthetic agent for pterygium surgery.

METHODS

We conducted a prospective, randomized clinical trial. Fifty-four consecutive patients who had primary pterygium underwent surgical excision of the lesion and conjunctival autograft. Patients were randomized into two groups. Group 1 received 1 ml of lidocaine 2% solution subconjunctivally and group 2 received lidocaine 2% gel topically. The primary outcome of interest was the pain experienced during anaesthetic administration and surgery. Following the dissection and excision of the pterygium, conjunctival autograft was transplanted in each of the patients. Immediately after the operation, pain and discomfort scores were determined using a 10-point linear visual analogue scale.

RESULTS

The mean pain score during anaesthetic administration was 4.26 +/- 1.18 in the injection group and 0.92 +/- 0.56 in the gel group. The mean pain score during surgery was 3.96 +/- 0.95 in the injection group and 4.0 +/- 1.01 in the gel group. There was a statistically significant difference in mean pain scores experienced during anaesthetic administration (p = 0.01). There was no significant difference in mean pain scores experienced during surgery (p = 0.55). No adverse events were noted.

CONCLUSION

In light of these results, we conclude that topical administration of lidocaine 2% gel can be used as an alternative method of anaesthesia in pterygium surgery, especially for patients with needle phobia.

摘要

目的

翼状胬肉手术中的麻醉通常通过局部注射麻醉药物来实现。本研究的目的是确定2%利多卡因凝胶是否是翼状胬肉手术有效的局部麻醉剂。

方法

我们进行了一项前瞻性随机临床试验。54例连续的原发性翼状胬肉患者接受了病变的手术切除和结膜自体移植。患者被随机分为两组。第1组结膜下注射1ml 2%利多卡因溶液,第2组局部应用2%利多卡因凝胶。主要关注的结果是麻醉给药和手术期间经历的疼痛。在翼状胬肉切除术后,对每位患者进行结膜自体移植。手术后立即使用10分线性视觉模拟量表确定疼痛和不适评分。

结果

注射组麻醉给药期间的平均疼痛评分为4.26±1.18,凝胶组为0.92±0.56。注射组手术期间的平均疼痛评分为3.96±0.95,凝胶组为4.0±1.01。麻醉给药期间经历的平均疼痛评分有统计学显著差异(p = 0.01)。手术期间经历的平均疼痛评分无显著差异(p = 0.55)。未观察到不良事件。

结论

根据这些结果,我们得出结论,局部应用2%利多卡因凝胶可作为翼状胬肉手术的替代麻醉方法,特别是对于有针头恐惧症的患者。

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