Akkaya Hampar, Dogan Oner, Agan Mehmet, Dincol Guncag
Pathology Department, Baskent University, Medical Faculty, Alanya Medical Center, 07400 Alanya-Antalya, Turkey.
APMIS. 2005 Mar;113(3):162-6. doi: 10.1111/j.1600-0463.2005.apm1130302.x.
Hairy cell leukemia (HCL) is a rare chronic B-cell lymphoproliferative disorder characterized by splenomegaly, pancytopenia, and circulating atypical lymphocytes with circumferential cytoplasmic projections. We investigated the specificity and the sensitivity of anti-TRAP antibody immunoreactivity in 57 cases of HCL. We found that there is a statistically highly significant difference between TRAP immunoreactivities of the study and the control groups, and HCL can be diagnosed by TRAP immunoreactivity in bone marrow trephine biopsy materials with a specificity of 98.27 % and a sensitivity of 100%.
毛细胞白血病（HCL）是一种罕见的慢性B细胞淋巴增殖性疾病，其特征为脾肿大、全血细胞减少以及循环中带有周边胞质突起的非典型淋巴细胞。我们研究了抗TRAP抗体免疫反应性在57例毛细胞白血病中的特异性和敏感性。我们发现，研究组与对照组的TRAP免疫反应性之间存在统计学上的高度显著差异，并且通过骨髓环钻活检材料中的TRAP免疫反应性可诊断毛细胞白血病，其特异性为98.27%，敏感性为100%。
