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本文引用的文献

1
Consensus report on the use of somatostatin analogs for the management of neuroendocrine tumors of the gastroenteropancreatic system.生长抑素类似物用于胃肠胰系统神经内分泌肿瘤管理的共识报告
Ann Oncol. 2004 Jun;15(6):966-73. doi: 10.1093/annonc/mdh216.
2
Somatostatin receptors in gastroentero-pancreatic neuroendocrine tumours.胃肠胰神经内分泌肿瘤中的生长抑素受体
Endocr Relat Cancer. 2003 Dec;10(4):451-8. doi: 10.1677/erc.0.0100451.
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Diagnosis and treatment of carcinoid tumors.类癌肿瘤的诊断与治疗
Expert Rev Anticancer Ther. 2003 Dec;3(6):863-77. doi: 10.1586/14737140.3.6.863.
4
Somatostatin receptors 2 and 5 are the major somatostatin receptors in insulinomas: an in vivo and in vitro study.生长抑素受体2和5是胰岛素瘤中的主要生长抑素受体：一项体内和体外研究。
J Clin Endocrinol Metab. 2003 Nov;88(11):5353-60. doi: 10.1210/jc.2002-021895.
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An in vivo OctreoScan-negative adrenal pheochromocytoma expresses somatostatin receptors and responds to somatostatin analogs treatment in vitro.
Horm Metab Res. 2003 Jun;35(6):349-54. doi: 10.1055/s-2003-41355.
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Somatostatin receptor subtype 1 selective activation in human growth hormone (GH)- and prolactin (PRL)-secreting pituitary adenomas: effects on cell viability, GH, and PRL secretion.生长抑素受体1亚型在分泌人生长激素（GH）和催乳素（PRL）的垂体腺瘤中的选择性激活：对细胞活力、GH和PRL分泌的影响。
J Clin Endocrinol Metab. 2003 Jun;88(6):2797-802. doi: 10.1210/jc.2002-021825.
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Somatostatin and somatostatin receptor physiology.生长抑素与生长抑素受体生理学
Endocrine. 2003 Apr;20(3):255-64. doi: 10.1385/ENDO:20:3:255.
8
A 5-decade analysis of 13,715 carcinoid tumors.对13715例类癌肿瘤的五十年分析。
Cancer. 2003 Feb 15;97(4):934-59. doi: 10.1002/cncr.11105.
9
Proliferation of antigen MIB-1 in metastatic carcinoid tumours removed at liver transplantation: relevance to prognosis.
Eur J Gastroenterol Hepatol. 2003 Feb;15(2):139-43. doi: 10.1097/00042737-200302000-00006.
10
Somatostatin analogues in the treatment of endocrine tumors of the gastrointestinal tract.生长抑素类似物在胃肠道内分泌肿瘤治疗中的应用
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缓释兰瑞肽治疗隐匿性类癌瘤肝转移的疗效消退

Regression of liver metastases of occult carcinoid tumor with slow release lanreotide therapy.

作者信息

Bondanelli Marta, Ambrosio Maria Rosaria, Zatelli Maria Chiara, Cavazzini Luigi, Al Jandali Rifa'y Laura, degli Uberti Ettore C

机构信息

Department of Biomedical Sciences and Advanced Therapies, Section of Endocrinology, University of Ferrara, Via Savonarola, 9, 44100 Ferrara, Italy.

出版信息

World J Gastroenterol. 2005 Apr 7;11(13):2041-4. doi: 10.3748/wjg.v11.i13.2041.

DOI:10.3748/wjg.v11.i13.2041
PMID:15801004
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4305735/
Abstract

Few clinical studies have demonstrated an anti-proliferative activity of somatostatin (SST) analogs in carcinoids. We report the case of a woman with liver metastases of neuroendocrine tumor and no evidence of the primary tumor. The liver metastases were characterized by high proliferation index, immunoreactiviy for somatostatin receptor (SSTR)-1, 2, 3 and 5 and positive octreoscan. Urinary 5-hydroxyindolacetic acid, serum serotonin and chromogranin A were elevated. Slow release lanreotide (SR-LAN) therapy for 3 mo controlled clinical and biochemical signs of carcinoid tumor and caused a clear-cut reduction in the diameter of two liver metastases and disappearance of another lesion, with further reduction after 6 and 18 mo. We demonstrated a clear-cut long-lasting anti-proliferative effect of SR-LAN on liver metastases of occult carcinoid with high proliferation index and immunoreactivity for SSTR-1, 2, 3, and 5. Immuno-histochemistry for SSTRs could be a suitable method for the selection of patients with metastatic carcinoid that may benefit from SST analog therapy.

摘要

很少有临床研究证实生长抑素（SST）类似物在类癌中有抗增殖活性。我们报告了一例患有神经内分泌肿瘤肝转移且无原发性肿瘤证据的女性病例。肝转移灶的特征为增殖指数高、对生长抑素受体（SSTR）-1、2、3和5免疫反应阳性且奥曲肽扫描呈阳性。尿5-羟吲哚乙酸、血清5-羟色胺和嗜铬粒蛋白A升高。长效兰瑞肽（SR-LAN）治疗3个月控制了类癌肿瘤的临床和生化体征，并使两个肝转移灶的直径明显缩小，另一个病灶消失，6个月和18个月后进一步缩小。我们证明了SR-LAN对具有高增殖指数且对SSTR-1、2、3和5免疫反应阳性的隐匿性类癌肝转移灶有明确的持久抗增殖作用。SSTRs免疫组化可能是选择可能从SST类似物治疗中获益的转移性类癌患者的合适方法。