1例大动脉炎合并肾小球肾炎，酷似膜增生性肾小球肾炎。
A case of Takayasu arteritis complicated with glomerulonephropathy mimicking membranoproliferative glomerulonephritis.
作者信息
Kuroda Takeshi, Ohbayashi Hiroaki, Murakami Syuuichi, Ito Satoshi, Sakatsume Minoru, Ueno Mitsuhiro, Nishi Shinichi, Nakano Masaaki, Gejyo Fumitake
机构信息
Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-Dori, 951-8510 Niigata City, Japan.
出版信息
Clin Rheumatol. 2004 Dec;23(6):536-40. doi: 10.1007/s10067-004-0936-1.
We report on a 65-year-old Japanese woman with Takayasu arteritis who developed severe proteinuria, hypertension, and renal dysfunction. Renal angiography demonstrated moderate irregular narrowing of both renal arteries. Renal biopsy showed glomerulonephropathy mimicking membranoproliferative glomerulonephritis (MPGN) with glomerular capillary wall thickening ("double contour") accompanied by mesangial cell proliferation and moderate increase of mesangial matrix without deposits of C3. Electron microscopy showed no subendothelial deposit and no circumferential mesangial interposition (CMI), and these findings are different from MPGN. In this report we present a case of Takayasu arteritis associated with glomerulonephropathy mimicking MPGN.
我们报告了一名65岁的日本女性，患有大动脉炎，出现了严重蛋白尿、高血压和肾功能不全。肾血管造影显示双侧肾动脉中度不规则狭窄。肾活检显示肾小球肾炎，类似于膜增生性肾小球肾炎（MPGN），伴有肾小球毛细血管壁增厚（“双轨征”），系膜细胞增生，系膜基质中度增加，无C3沉积。电子显微镜检查未发现内皮下沉积物和系膜周插入（CMI），这些发现与MPGN不同。在本报告中，我们展示了一例与类似MPGN的肾小球肾炎相关的大动脉炎病例。
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