Nishiyama Hiromi, Tanei Ryoji, Motegi Takashi, Ohta Masatsugu, Sawabe Motoji
Department of Dermatology, Tokyo Metropolitan Geriatric Hospital, 35-2 Sakaecho, Itabashi-ku, Tokyo 173-0015, Japan.
J Dermatol. 2004 Dec;31(12):1032-5. doi: 10.1111/j.1346-8138.2004.tb00650.x.
A 67-year-old female presented with diffuse edema, generalized telangiectasia, and indurated skin plaques. Histopathological findings of the skin lesion included CD45+/CD79+/CD20+ large lymphoma cells that filled the vascular lumina and infiltrated the subcutaneous tissues with panniculitic formations. Three cycles of a CHOP (cyclophosphamide, adriamycin, vincristine, and prednisolone) chemotherapy regimen resolved the skin manifestations. After five cycles of CHOP, however, she developed dementia-like symptoms. Three cycles of additional intrathecal chemotherapy (methotrexate, cytarabine and prednisolone) did not improve the neurological symptoms.
一名67岁女性出现弥漫性水肿、全身性毛细血管扩张和硬结性皮肤斑块。皮肤病变的组织病理学检查结果显示，CD45+/CD79+/CD20+大淋巴瘤细胞充满血管腔，并浸润皮下组织形成脂膜炎。三个周期的CHOP（环磷酰胺、阿霉素、长春新碱和泼尼松龙）化疗方案使皮肤症状得到缓解。然而，在接受五个周期的CHOP化疗后，她出现了类似痴呆的症状。三个周期的鞘内化疗（甲氨蝶呤、阿糖胞苷和泼尼松龙）未能改善神经症状。
