Watanabe T, Takahashi S
Department of Pediatrics, Nihon University School of Medicine, Japan.
Acta Paediatr Jpn. 1992 Feb;34(1):28-35. doi: 10.1111/j.1442-200x.1992.tb00921.x.
The urinary proteins of seven patients with asymptomatic low molecular weight proteinuria (ALMP) were compared with those of Lowe syndrome and Fanconi syndrome. A characteristic electrophoretic pattern was seen in ALMP by isoelectric focusing. Two dimensional electrophoresis revealed that the ALMP proteins were localized in a more negatively charged region of lower molecular weight and consisted of a smaller variety of proteins in comparison with those from Fanconi syndrome and Lowe syndrome. These results suggest that ALMP might be an isolated form of other types of congenital renal tubular diseases from the viewpoint of protein reabsorption and has a lesser functional defect on the proximal tubules.
将7例无症状性低分子量蛋白尿（ALMP）患者的尿蛋白与 Lowe 综合征和范科尼综合征患者的尿蛋白进行了比较。通过等电聚焦在ALMP中观察到一种特征性的电泳图谱。二维电泳显示，与范科尼综合征和Lowe综合征患者相比，ALMP蛋白位于分子量较低、带更多负电荷的区域，且蛋白质种类较少。这些结果表明，从蛋白质重吸收的角度来看，ALMP可能是其他类型先天性肾小管疾病的一种孤立形式，并且近端小管的功能缺陷较小。
