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经颈静脉肝内门体分流术患者的选择标准:现状

Selection criteria for patients undergoing transjugular intrahepatic portosystemic shunt procedures: current status.

作者信息

Ferral Hector, Patel Nilesh H

机构信息

Department of Radiology, Rush University Medical Center, 1725 West Harrison Street, Suite 456, Chicago, Illinois 60612-3833, USA.

出版信息

J Vasc Interv Radiol. 2005 Apr;16(4):449-55. doi: 10.1097/01.RVI.0000149508.64029.02.

Abstract

The transjugular intrahepatic portosystemic shunt (TIPS) procedure has a well-established role in the management of patients with complications of portal hypertension such as variceal bleeding or refractory ascites. Several clinical variables have been described to be associated with a poor prognosis after a TIPS procedure, including the presence of uncontrollable ascites, the number of sclerotherapy sessions to control a bleeding episode, the use of drugs for hemodynamic support, the use of balloon tamponade to control bleeding, the need for an emergency TIPS procedure, the need for mechanical ventilation, prothrombin time, increased serum creatinine, increased serum bilirubin, encephalopathy, and sepsis. In addition, several scoring systems have been developed and applied to patients undergoing TIPS procedures in an attempt to improve patient selection criteria for this invasive procedure. This article reviews the most important scoring systems that have been developed and applied to patients undergoing emergency or elective TIPS procedures, with particular emphasis on the prognostic index designed for patients undergoing emergency TIPS procedures and the Model for End-stage Liver Disease score designed for patients undergoing elective TIPS procedures. The most practical application of these scoring systems is probably that, with the information provided, the operator is able to discuss with referring physicians, patients, and family members the expected outcomes of this challenging procedure.

摘要

经颈静脉肝内门体分流术(TIPS)在门静脉高压并发症(如静脉曲张破裂出血或顽固性腹水)患者的治疗中具有明确的作用。已有多项临床变量被描述为与TIPS术后预后不良相关,包括存在难以控制的腹水、控制出血发作所需的硬化治疗次数、使用血流动力学支持药物、使用气囊压迫控制出血、需要急诊TIPS手术、需要机械通气、凝血酶原时间、血清肌酐升高、血清胆红素升高、肝性脑病和脓毒症。此外,已经开发了几种评分系统并应用于接受TIPS手术的患者,以试图改善这种侵入性手术的患者选择标准。本文回顾了已开发并应用于接受急诊或择期TIPS手术患者的最重要评分系统,特别强调了为接受急诊TIPS手术患者设计的预后指数和为接受择期TIPS手术患者设计的终末期肝病模型评分。这些评分系统最实际的应用可能是,根据所提供的信息,操作者能够与转诊医生、患者及其家属讨论这一具有挑战性手术的预期结果。

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